低碳水化合物饮食(LCD)由于其对健康结果的有利影响而引起了人们的兴趣,比如炎症。然而,需要进一步的研究来确定LCD对炎症参数的总体影响,但同时要考虑减肥和热量摄入。因此,对随机临床试验进行了系统评价和荟萃分析,以研究LCD与低脂饮食(LFDs)相比的效果。有和没有热量限制,成人炎症标志物。PubMed,Scopus,和WebofScience在2022年3月进行了搜索,以选择针对LCD和LCD的干预研究LFD,其中使用了以下循环炎症标志物:C反应蛋白(CRP),肿瘤坏死因子α(TNF-α),和白细胞介素(IL-6)。进行了比较LCD与LCD的分析。使用随机效应模型通过加权平均差(WMD)或标准化平均差(SMD)和95%置信区间(95%CIs)进行LFD。系统评价和荟萃分析共包括51项研究,总样本为4,164名成年人,有或没有其他慢性疾病。干预持续时间为2-144周。LCD,与LFD相比,体重显著下降[WMD=-1.35%,p=0.001],CRP[SMD=-0.1,p=0.03],和IL-6[SMD=-0.15,p=0.09]。然而,与LFD相比,LCD没有显着降低TNF-α[SMD=-0.02,p=0.7]。总之,LCD通过降低CRP和IL-6对炎症标志物具有有益作用;这种作用与体重减轻有关。然而,LCD在降低TNF-α方面并不比LFD更有效。
Low-carbohydrate diets (LCDs) have gained interest due to their favorable effects on health outcomes, such as inflammation. However, further research is needed to ascertain the overall effects of LCDs on inflammatory parameters, but at the same time considering weight loss and calorie intake. Thus, a systematic
review and meta-analysis of randomized clinical trials was performed to investigate the effects of LCDs compared with low-fat diets (LFDs), with and without caloric restriction, on inflammatory markers in adults. PubMed, Scopus, and Web of Science were searched through March 2022 to select intervention studies addressing LCDs vs. LFDs, in which the following circulating inflammatory markers were used: C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and interleukin (IL-6). Analyses were conducted comparing LCDs vs. LFDs through weighted mean differences (WMD) or standardized mean differences (SMD) and 95% confidence intervals (95% CIs) using random effects models. The systematic
review and meta-analysis included a total of 51 studies with a total sample of 4,164 adults, with or without other chronic diseases. Intervention durations ranged from 2-144 weeks. LCDs, compared with LFDs, significantly decreased body weight [WMD = -1.35%, p = 0.001], CRP [SMD = -0.1, p = 0.03], and IL-6 [SMD = -0.15, p = 0.09]. However, LCDs did not significantly decrease TNF-α [SMD = -0.02, p = 0.7] compared to LFDs. In conclusion, LCDs have a beneficial effect on markers of inflammation by decreasing CRP and IL-6; this effect has an association with weight loss. However, LCDs were not more effective than LFDs in decreasing TNF-α.