黄酮类化合物是植物中丰富的重要生物活性酚类化合物,具有不同的治疗潜力。伤口是糖尿病个体中的重要问题。高血糖环境改变了正常的伤口愈合过程,增加了微生物感染的风险,导致住院,发病率,和截肢。黄酮类化合物是一类重要的植物化学物质,具有优异的抗氧化剂,抗炎,抗菌,抗糖尿病药,抗肿瘤,和伤口愈合特性。槲皮素,橙皮苷,姜黄素,山奈酚,芹菜素,木犀草素,Morin,等。显示了伤口愈合的潜力.黄酮类化合物有效地表现出抗菌活性,清除活性氧,增加内源性抗氧化剂,减少炎症细胞因子的表达和合成(即IL-1β,IL-6,TNF-α,NF-κB),抑制炎症酶,增强抗炎细胞因子(IL-10),增强胰岛素切片,减少胰岛素抵抗,控制血糖水平。几种类黄酮如橙皮苷,姜黄素,槲皮素,芦丁,柚皮苷,和木犀草素已经显示出它们在治疗糖尿病伤口方面的潜力。维持葡萄糖止血的天然产物,发挥抗炎活性,抑制/抑制微生物生长,调节细胞因子,抑制基质金属蛋白酶(MMP),刺激血管生成和细胞外基质,和调节生长因子可以被认为是治疗糖尿病伤口的潜在治疗导向。发现黄酮类化合物通过调节MMP-2,MMP-8,MMP-9,MMP-13,Ras/Raf/MEK/ERK在糖尿病伤口的管理中起积极作用。PI3K/Akt,和一氧化氮途径。因此,可以认为黄酮类化合物可能是预防糖尿病伤口破坏性影响的潜在疗法。本文重点介绍了黄酮类化合物在糖尿病创面治疗中的潜在作用,并讨论了其可能的作用机制。
Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyperglycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, antitumor, and wound healing property. Quercetin, hesperidin, curcumin, kaempferol, apigenin, luteolin, morin, etc. have shown their wound healing potential. Flavonoids effectively exhibit antimicrobial activity, scavenge reactive oxygen species, augment endogenous antioxidants, reduce the expression and synthesis of inflammatory cytokines (i.e. IL-1β, IL-6, TNF-α, NF-κB), inhibit inflammatory enzymes, enhance anti-inflammatory cytokine (IL-10), enhance insulin section, reduce insulin resistance, and control blood glucose level. Several flavonoids like hesperidin, curcumin, quercetin, rutin, naringin, and luteolin have shown their potential in managing diabetic wounds. Natural products that maintain glucose haemostatic, exert anti-inflammatory activity, suppress/inhibit microbial growth, modulate cytokines, inhibit matrix metalloproteinase (MMP), stimulate angiogenesis and extracellular matrix, and modulate growth factor can be considered as a potential therapeutic lead to treat diabetic wound. Flavonoids were found to play a positive role in management of diabetic wounds by regulating MMP-2, MMP-8, MMP-9, MMP-13, Ras/Raf/ MEK/ERK, PI3K/Akt, and nitric oxide pathways. Therefore, it can be assumed that flavonoids could be potential therapeutics to prevent devastating effects of diabetic wounds. This paper focused on the potential role of flavonoids in managing diabetic wounds and discussed their possible mechanism of action.