PDF(Pubmed)
Abstract：
Diabetic wounds are one of the most challenging public health issues of the 21st century due to their inadequate vascular supply, bacterial infections, high levels of oxidative stress, and abnormalities in antioxidant defenses, whereas there is no effective treatment for diabetic wounds. Due to the distinct properties of nanoparticles, such as their small particle size, elevated cellular uptake, low cytotoxicity, antibacterial activity, good biocompatibility, and biodegradability. The application of nanoparticles has been widely used in the treatment of diabetic wound healing due to their superior anti-inflammatory, antibacterial, and antioxidant activities. These nanoparticles can also be loaded with various agents, such as organic molecules (eg, exosomes, small molecule compounds, etc.), inorganic molecules (metals, nonmetals, etc.), or complexed with various biomaterials, such as smart hydrogels (HG), chitosan (CS), and hyaluronic acid (HA), to augment their therapeutic potential in diabetic wounds. This paper reviews the therapeutic potential and future perspective of nanoparticles in the treatment of diabetic wounds. Together, nanoparticles represent a promising strategy in the treatment of diabetic wound healing. The future direction may be to develop novel nanoparticles with multiple effects that not only act in wound healing at all stages of diabetes but also provide a stable physiological environment throughout the wound-healing process.
摘要：
由于血管供应不足，糖尿病伤口是21世纪最具挑战性的公共卫生问题之一，细菌感染,高水平的氧化应激，和抗氧化防御的异常，而糖尿病伤口没有有效的治疗方法。由于纳米粒子的独特性质，比如它们的小粒径，细胞摄取升高，低细胞毒性，抗菌活性，良好的生物相容性,和生物降解性。纳米粒子因具有优越的抗炎、抗炎等长处，已被普遍运用于糖尿病创面的医治，抗菌，和抗氧化活性。这些纳米颗粒还可以装载各种试剂，如有机分子(如，外泌体,小分子化合物,等。),无机分子(金属，非金属,等。),或者与各种生物材料复合，如智能水凝胶(HG)，壳聚糖（CS），和透明质酸（HA），以增强它们在糖尿病伤口中的治疗潜力。本文综述了纳米颗粒在糖尿病伤口治疗中的治疗潜力和未来前景。一起,纳米颗粒代表了糖尿病伤口愈合治疗的一种有希望的策略。未来的方向可能是开发具有多种作用的新型纳米颗粒，这些纳米颗粒不仅在糖尿病的所有阶段的伤口愈合中起作用，而且在整个伤口愈合过程中提供稳定的生理环境。
