背景:粗糙度,下垂,在接受LH-RH类似物联合他莫昔芬或芳香化酶抑制剂辅助手术后内分泌治疗的乳腺癌患者中,皮疹较为常见.局部使用视黄醇(维生素A)已被证明是有效的美容治疗。
目的:使用基于3%视黄醇的高级视黄醇剥离制剂进行剥离,4%柠檬酸三乙酯,0.1%氨性粒细胞,没药醇,和1%的维生素E乙酸酯,在载体中的醇溶液已成功地用于改善患有光损伤的受试者和老年人群的皮肤外观。我们旨在验证其在辅助化疗期间的使用。
方法:四名在乳腺癌术后辅助治疗期间出现皮肤问题的受试者在停止术后治疗后至少6周接受视黄醇剥皮治疗,作为一种低侵入性美容治疗,可在皮肤科和家中使用。
结果:视黄醇皮有效,安全,和良好的耐受性,改善所有患者的皮肤亮度和紧致度,自4周后开始治疗。患者宣布对治疗和他们的皮肤外观感到满意,让他们对癌症康复感觉更好,也是。
结论:这些初步观察表明,晚期视黄醇剥离制剂的使用可能会改善乳腺癌手术后辅助治疗引起皮肤损伤的女性的皮肤外观。
BACKGROUND: Roughness, sagging, and skin rash are common in patients with breast cancer treated with LH-RH analog plus tamoxifen or aromatase inhibitors as adjuvant postsurgical endocrine therapy. The use of topical retinol (vitamin A) has shown to be an efficacious cosmetic treatment.
OBJECTIVE: Peeling with an advanced retinol peel formulation based on 3% retinol, 4% triethyl citrate, 0.1% aminophil, bisabolol, and 1% vitamin E acetate, in a vehicle in an alcoholic solution has been successfully used to ameliorate skin appearance on subjects with photodamage and in the aged population. We aimed to verify its use during adjuvant chemotherapy.
METHODS: Four subjects experiencing skin issues during postsurgical adjuvant therapy for their breast cancer received retinol peel at least 6 weeks after stopping their postsurgery therapy as a low invasive aesthetic medical treatment to be used both at the dermatology desk and at home.
RESULTS: Retinol peel was effective, safe, and well-tolerated, improving skin brightness and firmness in all the patients, since 4 weeks after the beginning of the treatment. Patients declared to be satisfied with the treatment and their skin appearance letting them feel better for cancer recovery, too.
CONCLUSIONS: These preliminary observations suggest that the use of an advanced retinol peel formulation might improve skin appearance in women experiencing skin damages caused by adjuvant therapy after breast cancer surgery.