背景:产生碳青霉烯酶的肠杆菌科是迄今为止最公共卫生和最紧迫的临床抗生素耐药性问题。它们导致住院时间延长,更昂贵的医疗,和更高的死亡率。这项系统评价和荟萃分析旨在表明埃塞俄比亚产生碳青霉烯酶的肠杆菌科细菌的患病率。
方法:本系统综述和荟萃分析是根据系统综述和荟萃分析指南的首选报告项目进行的。像PubMed这样的电子数据库,谷歌学者,CINAHL,Wiley在线图书馆,非洲在线杂志,科学直接,Embase,ResearchGate,Scopus,和WebofSciences被用来查找相关文章。此外,使用JoannaBriggs研究所质量评估工具对纳入研究的质量进行评估.采用Stata14.0进行统计分析。异质性评估采用Cochran的Q检验和I2统计量。此外,使用漏斗图和Egger检验评估发表偏倚。使用随机效应模型来估计合并的患病率。同时进行亚组和敏感性分析。
结果:埃塞俄比亚产碳青霉烯酶肠杆菌科的总体合并患病率为5.44%(95%CI3.97,6.92)。埃塞俄比亚中部患病率最高[6.45%(95%CI3.88,9.02)],和最低[(1.65%(95%CI0.66,2.65)]在南方国家和民族地区。就出版年份而言,2017-2018年合并患病率最高[17.44(95%CI8.56,26.32)],2015-2016年最低[2.24%(95%CI0.87,3.60)]。
结论:本系统综述和荟萃分析显示,产碳青霉烯酶的肠杆菌科细菌的患病率很高。所以,改变抗生素的常规使用,定期进行药敏试验,加强感染预防方法,需要对碳青霉烯耐药谱及其在肠杆菌科临床分离株中的决定基因进行额外的国家监测。
背景:PROSPERO(2022:CRD420223440181)。
BACKGROUND: Carbapenemase-producing Enterobacteriaceae are by far the most public health and urgent clinical problems with antibiotic resistance. They cause longer hospital stays, more expensive medical care, and greater mortality rates. This systematic
review and meta-analysis aimed to indicate the prevalence of
carbapenemase-producing Enterobacteriaceae in Ethiopia.
METHODS: This systematic
review and meta-analysis was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Electronic databases like PubMed, Google Scholar, CINAHL, Wiley Online Library, African Journal Online, Science Direct, Embase, ResearchGate, Scopus, and the Web of Sciences were used to find relevant articles. In addition, the Joanna Briggs Institute quality appraisal tool was used to assess the quality of the included studies. Stata 14.0 was used for statistical analysis. Heterogeneity was assessed by using Cochran\'s Q test and I2 statistics. In addition, publication bias was assessed using a funnel plot and Egger\'s test. A random effect model was used to estimate the pooled prevalence. Sub-group and sensitivity analysis were also done.
RESULTS: The overall pooled prevalence of
carbapenemase-producing Enterobacteriaceae in Ethiopia was 5.44% (95% CI 3.97, 6.92). The prevalence was highest [6.45% (95% CI 3.88, 9.02)] in Central Ethiopia, and lowest [(1.65% (95% CI 0.66, 2.65)] in the Southern Nations and Nationalities People Region. In terms of publication year, 2017-2018 had the highest pooled prevalence [17.44 (95% CI 8.56, 26.32)] and 2015-2016 had the lowest [2.24% (95% CI 0.87, 3.60)].
CONCLUSIONS: This systematic
review and meta-analysis showed a high prevalence of
carbapenemase-producing Enterobacteriaceae. So, to alter the routine use of antibiotics, regular drug susceptibility testing, strengthening the infection prevention approach, and additional national surveillance on the profile of carbapenem resistance and their determining genes among Enterobacteriaceae clinical isolates are required.
BACKGROUND: PROSPERO (2022: CRD42022340181).