Abstract：
Carbapenem antibiotics are considered one of the most effective and the last-resort antibiotics for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, with the advent of carbapenem resistance, it becomes obvious that quality health-care delivery will be hampered if adequate measure is not put in place. This review assessed the prevalence of carbapenem-resistant Gram-negative bacteria (CR-GNB) and also provided an up-to-date position on carbapenem resistance (CR) in Nigeria. Three electronic databases (Google Scholar, PubMed and African Journal online) were searched for relevant literatures, and 38 articles published between January 2013 and June 2022 that met the criteria for inclusion were recruited into the study. The mean prevalence of CR in Nigeria stands at 21.3%, with the southern and northern regions documenting a mean prevalence of 22.0% and 20.9%, respectively. Most of the reviewed articles were from clinical settings (81.6%), with urine samples (38.7%) constituting the most prevalent clinical sample in which CR-GNB were detected. The preponderance of phenotypic methods (55.3%) over molecular method (44.7%), particularly the use of disk diffusion test breakpoint and Modified Hodge test was documented. The most prevalent carbapenem-resistant bacteria were Escherichia coli (50.0%) and Klebsiella pneumoniae (26.3%). The blaNDM and blaVIM were the major reported carbapenemase-encoded genes, particularly among E. coli, K. pneumoniae and Pseudomonas species. This systematic review revealed a mean prevalence of CR-GNB in Nigeria that required urgent attention. Furthermore, the detection of clinically and epidemiologically important carbapenemase coding genes is of public health importance.
摘要：
碳青霉烯类抗生素被认为是治疗由多重耐药革兰氏阴性菌引起的感染的最有效和最后手段的抗生素之一。然而,随着碳青霉烯耐药性的出现，很明显，如果不采取适当措施，高质量的医疗保健服务将受到阻碍。这篇综述评估了耐碳青霉烯革兰氏阴性菌（CR-GNB）的患病率，并提供了尼日利亚耐碳青霉烯（CR）的最新情况。三个电子数据库(谷歌学者，PubMed和非洲杂志在线)搜索相关文献，在2013年1月至2022年6月期间发表的符合纳入标准的38篇文章被纳入研究.尼日利亚CR的平均患病率为21.3%，南部和北部地区的平均患病率为22.0％和20.9％，分别。大多数审查的文章来自临床环境(81.6%)，尿液样本（38.7％）构成了检测到CR-GNB的最普遍的临床样本。表型方法(55.3%)优于分子方法(44.7%)，特别是使用圆盘扩散试验断点和改良Hodge试验。碳青霉烯类耐药菌为大肠埃希菌(50.0%)和肺炎克雷伯菌(26.3%)。blaNDM和blaVIM是主要报道的碳青霉烯酶编码基因，特别是在大肠杆菌中，肺炎克雷伯菌和假单胞菌。这项系统评价揭示了尼日利亚CR-GNB的平均患病率，需要紧急关注。此外，临床和流行病学上重要的碳青霉烯酶编码基因的检测对公众健康具有重要意义.
