PDF(Pubmed)
Abstract：
New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales was first detected in Brazil in 2014, in a Providencia rettgeri isolate recovered from surveillance swabs in the Southern region. Since then, an increasing number of NDM enzymes have been reported in different species. Nevertheless, comprehensive data on the current epidemiology of NDM-producing Enterobacterales in Brazil are lacking. Therefore, this study reviewed the available information on the status of NDM-producing bacteria in Brazil. The main finding was the diversity of bacteria producing NDM, including Klebsiella, Enterobacter, Morganella, Proteus, Escherichia, and Providencia. Limited data on clonality are available, but a few studies report different clonal backgrounds in NDM-producing K. pneumoniae, likely indicating local outbreaks. Over the years, a rise in the number of reported strains in different locations has been verified; however, different biases may have contributed to this finding. Therefore, a national surveillance study is warranted to identify the actual prevalence and incidence of NDM-producing Enterobacterales in Brazil and their role in patient management and outcome.
摘要：
2014年在巴西首次发现了产生新德里金属β-内酰胺酶（NDM）的肠杆菌，该细菌是从南部地区的监视拭子中回收的Providenciarettgeri分离物中。从那以后,越来越多的NDM酶已经在不同的物种中被报道。然而，目前缺乏巴西产NDM肠杆菌流行病学的综合数据。因此,本研究回顾了巴西NDM产生菌的现有信息。主要发现是产生NDM的细菌的多样性，包括克雷伯菌,肠杆菌,Morganella,Proteus,埃希氏菌,还有普罗维登西亚.关于克隆性的数据有限，但是一些研究报告了产生NDM的肺炎克雷伯菌的不同克隆背景，可能表明当地爆发。多年来,已证实不同地点报告的菌株数量有所增加；然而，不同的偏见可能促成了这一发现。因此,有必要进行一项国家监测研究,以确定巴西产NDM肠杆菌的实际患病率和发病率,以及它们在患者管理和结局中的作用.
