OXA-48 Carbapenemase-Producing Salmonella typhimurium Nosocomial Bacteremia in the Intensive Care Unit: A Case Report and Review of the Literature.

重症监护病房中产生 OXA - 48 碳青霉烯酶的鼠伤寒沙门氏菌医院内菌血症 ： 病例报告和文献回顾。

• 发表时间: Mar 2023
• 来源期刊: Cureus
• DOI: 10.7759/cureus.35811
• PMID: 37033565
• 文章类型: Case Reports
• 作者列表: Debbagh F,Idam F,Lamrani Hanchi A,Soraa N

关键词: bacteremia; blaoxa-48; carbapenemase; intensive care unit; nosocomial infection; salmonella typhimurium; surgical wound infection

Abstract

Salmonella enterica serovar Typhimurium is a gram-negative bacterium mainly involved in foodborne diseases. Several pathways of antimicrobial resistance have been recently identified in this strain. This article reports a case of a patient hospitalized in intensive care who underwent emergency trauma surgery. During his hospitalization, he developed a nosocomial bacteremia from a surgical wound infection. The cytobacteriological examination of the surgical site and the blood culture isolated Salmonella spp. susceptible to third-generation cephalosporins, resistant to ertapenem, and with decreased sensitivity to imipenem. The carbapenemase test was positive for blaOXA-48. The serotyping identified Salmonella enterica serovar Typhimurium. The patient\'s response to antibiotics was favorable.

摘要

伤寒沙门氏菌是一种主要参与食源性疾病的革兰氏阴性菌。最近已经在该菌株中鉴定了几种抗微生物抗性途径。本文报道了一例重症监护住院的患者，该患者接受了紧急创伤手术。在他住院期间,他因手术伤口感染而发展为医院内菌血症。手术部位的细胞细菌学检查和血液培养分离的沙门氏菌。对第三代头孢菌素敏感,对厄他培南有抗性,对亚胺培南的敏感性降低。碳青霉烯酶试验对blaOXA-48呈阳性。血清分型鉴定为鼠伤寒沙门氏菌。患者对抗生素的反应良好。