■更年期对女性构成重大健康风险,特别是与骨质疏松症相关的骨折的脆弱性增加。饮食干预已成为有希望的策略,专注于减轻骨质疏松症的风险,而不是仅仅解决既定的疾病。这项为期12周的随机对照试验旨在分析食用嗜酸乳杆菌益生菌对钙水平的影响,骨代谢的生物标志物,绝经后妇女的骨密度(BMD)。
55名参与者被随机分配通过口服干预每天接受安慰剂(n=25)或益生菌嗜酸乳杆菌UALa-01™(n=30)。在整个研究过程中,评估包括身体成分,血液生化参数,血清钙水平,和骨代谢的生物标志物。此外,使用双能X射线吸收法测量BMD曲线。
■研究结果表明,益生菌组的血清钙水平与其初始水平相比有所下降。然而,头发钙水平和与骨代谢相关的生物标志物在该组中没有显着变化。益生菌嗜酸乳杆菌的消费似乎也可以防止骨转换标志物的波动。此外,腰椎的BMD水平没有明显改变,左股骨,和整个身体在益生菌组。此外,在干预期间,益生菌的摄入显著降低了体内脂肪和内脏脂肪,从而带来了良好的结局.相反,观察到食用益生菌嗜酸乳杆菌的不利影响,同时葡萄糖浓度显著增加.
■总而言之,在绝经后妇女中,每天食用嗜酸乳杆菌益生菌12周不会影响BMD的概况,但它可能有助于稳定骨转换。重要的是要注意,大多数测量参数在该人群的正常范围内。然而,值得注意的是,3个月的益生菌补充剂可能会潜在地破坏绝经后女性的钙和葡萄糖状态.
UNASSIGNED: Menopause poses significant health risks for women, particularly an increased vulnerability to fractures associated with osteoporosis. Dietary interventions have emerged as promising strategies, focusing on mitigating the risk of osteoporosis rather than solely addressing the established disease. This 12-week randomized controlled
trial aimed to analyze the effects of consuming Lactobacillus acidophilus probiotics on calcium levels, biomarkers of bone metabolism, and bone mineral density (BMD) profiles in postmenopausal women.
UNASSIGNED: Fifty-five participants were randomly assigned to receive either a placebo (n = 25) or the probiotic L. acidophilus UALa-01™ (n = 30) daily via oral intervention. Throughout the
study, evaluations included body composition, blood biochemical parameters, serum calcium levels, and biomarkers of bone metabolism. Additionally, Dual-energy X-ray absorptiometry was used to measure BMD profiles.
UNASSIGNED: The findings delineated that the probiotic group experienced a decrease in serum calcium levels compared to their initial levels. However, hair calcium levels and biomarkers related to bone metabolism showed no notable changes within this group. Consumption of probiotic L. acidophilus also seemed to prevent fluctuations in bone turnover markers. Moreover, there were no significant alterations in BMD levels at the lumbar spine, left femur, and total body in the probiotic group. Additionally, probiotic intake led to favorable outcomes by significantly reducing both body fat and visceral fat during the intervention period. Conversely, an adverse effect of consuming probiotic L. acidophilus was observed with a significant increase in glucose concentration.
UNASSIGNED: In conclusion, the consumption of L. acidophilus probiotics daily for 12 weeks among postmenopausal women does not affect the profile of BMD, but it may help in stabilizing bone turnover. It is important to note that most measured parameters were within the normal range for this population. However, it is worth noting that 3 months of probiotic supplementation could potentially disrupt calcium and glucose status in postmenopausal women.