{Reference Type}: Journal Article
{Title}: Vitamin D therapy in chronic kidney disease: a critical appraisal of clinical trial evidence.
{Author}: Yeung WG;Toussaint ND;Badve SV;
{Journal}: Clin Kidney J
{Volume}: 17
{Issue}: 8
{Year}: 2024 Aug
{Factor}: 5.86
{DOI}: 10.1093/ckj/sfae227
{Abstract}: In people with chronic kidney disease (CKD), the physiology of vitamin D is altered and leads to abnormalities in bone and mineral metabolism which contribute to CKD mineral and bone disorder (CKD-MBD). Observational studies show an association between vitamin D deficiency and increased risk of mortality, cardiovascular disease and fracture in CKD. Although vitamin D therapy is widely prescribed in people with CKD, clinical trials to date have failed to demonstrate a clear benefit of either nutritional vitamin D supplementation or active vitamin D therapy in improving clinical outcomes in CKD. This review provides an updated critical analysis of recent trial evidence on vitamin D therapy in people with CKD.