%0 Journal Article
%T Vitamin D therapy in chronic kidney disease: a critical appraisal of clinical trial evidence.
%A Yeung WG
%A Toussaint ND
%A Badve SV
%J Clin Kidney J
%V 17
%N 8
%D 2024 Aug
%M 39119524
%F 5.86
%R 10.1093/ckj/sfae227
%X In people with chronic kidney disease (CKD), the physiology of vitamin D is altered and leads to abnormalities in bone and mineral metabolism which contribute to CKD mineral and bone disorder (CKD-MBD). Observational studies show an association between vitamin D deficiency and increased risk of mortality, cardiovascular disease and fracture in CKD. Although vitamin D therapy is widely prescribed in people with CKD, clinical trials to date have failed to demonstrate a clear benefit of either nutritional vitamin D supplementation or active vitamin D therapy in improving clinical outcomes in CKD. This review provides an updated critical analysis of recent trial evidence on vitamin D therapy in people with CKD.