■骨质疏松性骨折是全球主要的公共卫生问题。人类对氨基酸(AAs)与骨折之间关联的研究仍然缺乏。
■研究AA与近期骨质疏松性骨折之间的关联。
这项年龄和性别相匹配的病例对照研究确定了吉林大学第二医院的44例近期X线确诊骨折病例和88例50岁以上的社区健康对照。通过高效液相色谱与质谱联用来测量血浆AAs。在调整协变量后(即,身体质量指数,牛奶摄入量>1次/周,跌倒和身体活动),我们采用条件逻辑回归模型来检验AA与骨折之间的关联.
■病例中有23例(52.3%)髋部骨折和21例(47.7%)非髋部骨折。总计,必要的,病例和非必要AAs显著低于对照组。在多变量条件逻辑回归模型中,在调整协变量后,总标准偏差增加(比值比[OR]:0.304;95%置信区间[CI]:0.117-0.794),原发性(OR:0.408;95%CI:0.181-0.923)和非原发性AA(OR:0.290;95CI:0.107-0.782)与近期骨折呈负相关。这些逆关联主要用于髋部骨折,而不是非髋部骨折。在这些AA中,赖氨酸,丙氨酸,精氨酸谷氨酰胺,组氨酸和哌丁胺与骨折呈显著负相关.
■AAs与最近的骨质疏松性骨折之间存在负相关关系;对于髋部骨折,这种关系似乎更为明显。
UNASSIGNED: Osteoporotic fracture is a major public health issue globally. Human research on the association between amino acids (AAs) and fracture is still lacking.
UNASSIGNED: To examine the association between AAs and recent osteoporotic fractures.
UNASSIGNED: This age and sex matched incident
case-control study identified 44 recent x-ray confirmed fracture cases in the Second Hospital of Jilin University and 88 community-based healthy controls aged 50+ years. Plasma AAs were measured by high performance liquid chromatography coupled with mass spectrometry. After adjusting for covariates (i.e., body mass index, milk intake >1 time/week, falls and physical activity), we conducted conditional logistical regression models to test the association between AAs and fracture.
UNASSIGNED: Among cases there were 23 (52.3%) hip fractures and 21 (47.7%) non-hip fractures. Total, essential, and non-essential AAs were significantly lower in cases than in controls. In the multivariable conditional logistic regression models, after adjusting for covariates, each standard deviation increase in the total (odds ratio [OR]: 0.304; 95% confidence interval [CI]: 0.117-0.794), essential (OR: 0.408; 95% CI: 0.181-0.923) and non-essential AAs (OR: 0.290; 95%CI: 0.107-0.782) was negatively associated with recent fracture. These inverse associations were mainly found for hip fracture, rather than non-hip fractures. Among these AAs, lysine, alanine, arginine, glutamine, histidine and piperamide showed the significantly negative associations with fracture.
UNASSIGNED: There was a negative relationship between AAs and recent osteoporotic fracture; such relationship appeared to be more obvious for hip fracture.