目的:本研究的目的是系统地回顾研究各种类型的再生医学方法(例如富血小板血浆,基质血管分数,细胞疗法,条件媒体,等。)用于治疗特定的皮肤病。复兴,疤痕,伤口愈合,和其他继发性皮肤损伤情况在这项研究中没有调查。
方法:主要数据库,包括PubMed,Scopus,和WebofScience,在2024年1月之前,我们精心搜索了RCT,重点是针对特定皮肤病的再生医学干预措施(如雄激素性脱发,白癜风,斑秃,等。).提取的关键数据包括参与者特征和样本量,再生疗法的类型,治疗功效,和不良事件。
结果:在本系统综述中,共检查了64项研究,涉及2888名患者。女性占研究人群的44.8%,而男性占参与者的55.2%,平均年龄27.64岁。最常见的皮肤病是雄激素性脱发(AGA)(45.3%)和白癜风(31.2%)。研究这些疾病的最常见的再生方法是PRP和自体表皮黑素细胞/角质形成细胞的移植,分别。研究报告AGA改善高达68.4%,白癜风改善高达71%。该综述中包括的其他疾病是斑秃,黄褐斑,硬化性萎缩性苔藓(LSA),炎性寻常痤疮,慢性静止原污水,糜烂性口腔扁平苔藓,营养不良性大疱性表皮松解症。在所有这些研究中,再生医学被发现是一种有效的治疗选择,以及其他方法。这项研究中研究的再生医学技术包括自体表皮黑素细胞/角质形成细胞的移植,分离的黑素细胞移植,毛囊起源的细胞移植,PRP中的黑素细胞-角质形成细胞悬浮液,条件培养基注射,PRP和碱性成纤维细胞生长因子的组合,静脉内注射间充质干细胞,集中生长因子,基质血管分数(SVF),PRP和SVF的组合,并在PRP中保存头发移植物。
结论:再生医学有望治疗特定的皮肤病。为了验证我们的发现,建议进行许多针对各种皮肤状况的临床试验。在我们的研究中,我们没有探索继发性皮肤损伤,如疤痕或溃疡。因此,评估这种治疗方法解决这些疾病的有效性需要进行单独的研究.
OBJECTIVE: The aim of this study is to systematically
review randomized controlled clinical trials (RCTs) studying various types of regenerative medicine methods (such as platelet-rich plasma, stromal vascular fraction, cell therapy, conditioned media, etc.) in treating specific dermatologic diseases. Rejuvenation, scarring, wound healing, and other secondary conditions of skin damage were not investigated in this study.
METHODS: Major databases, including PubMed, Scopus, and Web of Science, were meticulously searched for RCTs up to January 2024, focusing on regenerative medicine interventions for specific dermatologic disorders (such as androgenetic alopecia, vitiligo, alopecia areata, etc.). Key data extracted encompassed participant characteristics and sample sizes, types of regenerative therapy, treatment efficacy, and adverse events.
RESULTS: In this systematic
review, 64 studies involving a total of 2888 patients were examined. Women constituted 44.8% of the study population, while men made up 55.2% of the participants, with an average age of 27.64 years. The most frequently studied skin diseases were androgenetic alopecia (AGA) (45.3%) and vitiligo (31.2%). The most common regenerative methods investigated for these diseases were PRP and the transplantation of autologous epidermal melanocyte/keratinocyte cells, respectively. Studies reported up to 68.4% improvement in AGA and up to 71% improvement in vitiligo. Other diseases included in the
review were alopecia areata, melasma, lichen sclerosus et atrophicus (LSA), inflammatory acne vulgaris, chronic telogen effluvium, erosive oral lichen planus, and dystrophic epidermolysis bullosa. Regenerative medicine was found to be an effective treatment option in all of these studies, along with other methods. The regenerative medicine techniques investigated in this study comprised the transplantation of autologous epidermal melanocyte/keratinocyte cells, isolated melanocyte transplantation, cell transplantation from hair follicle origins, melanocyte-keratinocyte suspension in PRP, conditioned media injection, a combination of PRP and basic fibroblast growth factor, intravenous injection of mesenchymal stem cells, concentrated growth factor, stromal vascular fraction (SVF), a combination of PRP and SVF, and preserving hair grafts in PRP.
CONCLUSIONS: Regenerative medicine holds promise as a treatment for specific dermatologic disorders. To validate our findings, it is recommended to conduct numerous clinical trials focusing on various skin conditions. In our study, we did not explore secondary skin lesions like scars or ulcers. Therefore, assessing the effectiveness of this treatment method for addressing these conditions would necessitate a separate study.