PDF(Pubmed)
Abstract：
Androgenetic alopecia (AGA) is the most common cause of alopecia in males and females. Minoxidil and finasteride are the only FDA-approved treatments for AGA. New treatments including Platelet Rich Plasma (PRP) and microneedling have shown promising results. The purpose of this literature review was to highlight recent studies examining the effects of topical minoxidil combined with PRP to minoxidil or PRP monotherapy. The method used for this paper includes a systematic review of the literature from 2010 to 2022 using the PubMed, EMBASE, and MEDLINE databases examining studies evaluating combination therapies for AGA. Three randomized control trials compared combination PRP + topical 5% minoxidil to either no treatment, 5% minoxidil, or PRP only. Two studies found increased hair growth at five months and at six months following combined therapy. Another study found an increase in hair density and improved patient satisfaction with combination therapy compared to monotherapy. A prospective study revealed that patients treated with combined 5% minoxidil, PRP, and microneedling reported the highest patient and physician satisfaction compared to minoxidil monotherapy. An observational study evaluating topical 5% minoxidil with PRP reported an increase in hair diameter after one year of combination treatment compared to minoxidil monotherapy. PRP therapy combined with minoxidil and microneedling in a retrospective study was shown to increase hair growth compared to PRP with minoxidil as well as PRP or minoxidil monotherapy. In conclusion, a variety of studies demonstrated superior treatment response with a combination of PRP and minoxidil therapy in patients with AGA. Limitations to this study include different PRP preparation protocols, few randomized control studies, and small sample sizes.
摘要：
雄激素性脱发（AGA）是男性和女性脱发的最常见原因。米诺地尔和非那雄胺是唯一FDA批准的AGA治疗方法。包括富血小板血浆（PRP）和微针疗法在内的新疗法已显示出有希望的结果。这篇文献综述的目的是强调最近的研究，研究局部米诺地尔联合PRP对米诺地尔或PRP单一疗法的影响。本文使用的方法包括使用PubMed对2010年至2022年的文献进行系统回顾，EMBASE,和MEDLINE数据库检查评估AGA联合疗法的研究。三项随机对照试验比较了PRP+外用5%米诺地尔与不治疗的组合，5%米诺地尔,或仅PRP。两项研究发现，联合治疗后五个月和六个月的头发生长增加。另一项研究发现，与单一疗法相比，联合疗法的头发密度增加，患者满意度提高。一项前瞻性研究显示，联合使用5%米诺地尔治疗的患者，PRP,与米诺地尔单一疗法相比，微针报告的患者和医师满意度最高。评估局部5%米诺地尔与PRP的观察性研究报告,与米诺地尔单一疗法相比,组合治疗一年后毛发直径增加。与使用米诺地尔以及PRP或米诺地尔单一疗法的PRP相比,在回顾性研究中,与米诺地尔和微针结合的PRP疗法显示出增加毛发生长。总之,多项研究表明,在AGA患者中,PRP和米诺地尔联合治疗具有优异的治疗效果.这项研究的局限性包括不同的PRP制备方案，很少有随机对照研究，和小样本量。
