{Reference Type}: Journal Article
{Title}: Platelet-rich fibrin: A review of its role as a new treatment in androgenetic alopecia.
{Author}: Shrestha S;Pathak R;Jagat GC;Donovan J;
{Journal}: J Cosmet Dermatol
{Volume}: 23
{Issue}: 8
{Year}: 2024 Aug 20
{Factor}: 2.189
{DOI}: 10.1111/jocd.16333
{Abstract}: <B>BACKGROUND: </B>Androgenetic alopecia (AGA) is a major cause of hair loss resulting from a complex interplay between various genes and hormones with the result being follicular miniaturization and altered hair cycle dynamics. Platelet-rich plasma (PRP) has a well-established role as adjunctive therapy in AGA but there are many limitations of it. In an attempt to overcome the shortcomings of PRP, liquid platelet-rich fibrin (PRF) was developed.<BR><B>OBJECTIVE: </B>This article critically reviews the protocol for the preparation and clinical outcomes of PRF.<BR><B>METHODS: </B>The articles published so far in the English language regarding the preparation and clinical outcomes of PRF were reviewed.<BR><B>RESULTS: </B>Among five studies analyzing various centrifugation speeds and centrifugation times, three of the studies favored low-speed centrifugation, whereas two studies did not support this methodology. A horizontal centrifuge may be preferred over a fixed-angle centrifuge for PRF. Five clinical studies on the use of PRF showed a significant effect on AGA.<BR><B>CONCLUSIONS: </B>At present, there is no consensus regarding the preparation of PRF. Most studies used fixed-angle centrifugation favored low centrifuge speed and less centrifugation time. Larger studies are needed to determine the optimal centrifugation force and time. A horizontal centrifuge may be preferred over a fixed-angle centrifuge due to the higher yield of platelets, and lesser shear trauma to the cells. In addition, larger, well-designed studies are needed to confirm the benefits of PRF over PRP.