Abstract：
The ventral subiculum regulates emotion, stress responses, and spatial and social cognition. In our previous studies, we have demonstrated anxiety- and depression-like symptoms, deficits in spatial and social cognition in ventral subicular lesioned (VSL) rats, and restoration of affective and cognitive behaviors following photoperiod manipulation (short photoperiod regime, SPR; 6:18 LD cycle). In the present study, we have studied the impact of VSL on sleep-wake behavioral patterns and the effect of SPR on sleep-wakefulness behavior. Adult male Wistar rats subjected to VSL demonstrated decreased wake duration and enhanced total sleep time due to increased non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS). Power spectral analysis indicated increased delta activity during NREMS and decreased sigma band power during all vigilance states. Light is one of the strongest entrainers of the circadian rhythm, and its manipulation may have various physiological and functional consequences. We investigated the effect of 21-day exposure to SPR on sleep-wakefulness (S-W) behavior in VSL rats. We observed that SPR exposure restored S-W behavior in VSL rats, resulting in an increase in wake duration and a significant increase in theta power during wake and REMS. This study highlights the crucial role of the ventral subiculum in maintaining normal sleep-wakefulness patterns and highlights the effectiveness of photoperiod manipulation as a non-pharmacological treatment for reversing sleep disturbances reported in mood and neuropsychiatric disorders like Alzheimer\'s disease, bipolar disorder, and major depressive disorder, which also involve alterations in circadian rhythm.
摘要：
腹下膜调节情绪，应激反应，以及空间和社会认知。在我们之前的研究中,我们已经表现出类似焦虑和抑郁的症状，腹侧锁骨下病变（VSL）大鼠的空间和社会认知缺陷，和光周期操作后的情感和认知行为的恢复(短光周期制度，SPR；6:18LD循环)。在本研究中,我们研究了VSL对睡眠-觉醒行为模式的影响以及SPR对睡眠-觉醒行为的影响.由于非快速眼动睡眠（NREMS）和快速眼动睡眠（REMS）的增加，接受VSL的成年雄性Wistar大鼠的觉醒持续时间减少，总睡眠时间增加。功率谱分析表明，NREMS期间的delta活动增加，而在所有警戒状态下的sigma波段功率降低。光是昼夜节律最强的夹带剂之一，它的操作可能会产生各种生理和功能后果。我们研究了21天暴露于SPR对VSL大鼠睡眠觉醒（S-W）行为的影响。我们观察到SPR暴露可以恢复VSL大鼠的S-W行为，导致唤醒持续时间增加，并且在唤醒和REMS期间θ功率显着增加。这项研究强调了腹下膜在维持正常睡眠-觉醒模式中的关键作用，并强调了光周期操作作为一种非药物治疗方法的有效性，用于逆转情绪和神经精神疾病如阿尔茨海默病的睡眠障碍。双相情感障碍,和重度抑郁症,这也涉及昼夜节律的改变。
