PDF(Pubmed)
Abstract：
An implantable electrode based on bioresorbable Mg-Nd-Zn-Zr alloy was developed for next-generation radiofrequency (RF) tissue welding application, aiming to reduce thermal damage and enhance anastomotic strength. The Mg alloy electrode was designed with different structural features of cylindrical surface (CS) and continuous long ring (LR) in the welding area, and the electrothermal simulations were studied by finite element analysis (FEA). Meanwhile, the temperature variation during tissue welding was monitored and the anastomotic strength of welded tissue was assessed by measuring the avulsion force and burst pressure. FEA results showed that the mean temperature in the welding area and the proportion of necrotic tissue were significantly reduced when applying an alternating current of 110 V for 10 s to the LR electrode. In the experiment of tissue welding ex vivo, the maximum and mean temperatures of tissues welded by the LR electrode were also significantly reduced and the anastomotic strength of welded tissue could be obviously improved. Overall, an ideal welding temperature and anastomotic strength which meet the clinical requirement can be obtained after applying the LR electrode, suggesting that Mg-Nd-Zn-Zr alloy with optimal structure design shows great potential to develop implantable electrode for next-generation RF tissue welding application.
摘要：
开发了一种基于生物可吸收Mg-Nd-Zn-Zr合金的可植入电极，用于下一代射频（RF）组织焊接应用，旨在减少热损伤，提高吻合口强度。镁合金焊条在焊接区域设计了圆柱面(CS)和连续长环(LR)不同的结构特征,并通过有限元分析(FEA)对电热模拟进行了研究。同时,监测组织焊接过程中的温度变化，并通过测量撕脱力和爆裂压力评估焊接组织的吻合强度。FEA结果表明，当将110V的交流电施加到LR电极10s时，焊接区域的平均温度和坏死组织的比例显着降低。在离体组织焊接实验中，LR电极焊接组织的最高温度和平均温度也明显降低，焊接组织的吻合强度明显提高。总的来说,应用LR电极后可获得满足临床要求的理想焊接温度和吻合强度，表明，优化结构设计的Mg-Nd-Zn-Zr合金显示出开发用于下一代射频组织焊接应用的植入式电极的巨大潜力。
