目的:探讨光密度测定与圆锥角膜(KC)生物力学和形态学参数的相关性的临床意义,并验证光密度测定在KC中的诊断价值。
方法:这项横断面研究包括295例KC患者的436只眼。角膜光密度测定法,测量形态学参数和生物力学参数。采用Spearman的相关分析来研究光密度与生物力学和形态学参数之间的关联。
结果:前部(0-2mm和2-6mm)的光学密度测定,中央(0-2毫米),后(2-6mm)和总(2-6mm)层与SPA1呈正相关,而后层(0-2mm)呈负相关。前层2-6毫米的光学密度测定,6-10毫米,中央层6-10mm对AL1有负面影响,而后层0-2mm对AL1有正面影响。前部的光学密度测定,中央,和后层0-2毫米和2-6毫米积极影响形态参数K1F,K2F,KmF和K1B的绝对值,K2B,KmB.中心(0-2mm)和后部(2-6mm)层的光学密度测定对TCT产生负面影响。光学前(0-2毫米和2-6毫米)的密度测定,中心(0-2毫米),后(2-6毫米)和总(2-6毫米)层与ACE和PCE呈正相关,而后层(0-2mm)呈负相关。
结论:光密度测定与圆锥角膜的生物力学和形态学参数相关,提示其作为评估圆锥角膜进展和治疗效果的诊断指标的潜力。
OBJECTIVE: To investigate the clinical significance of the correlation between optical densitometry and both biomechanical and morphological parameters in keratoconus (KC) and to verify the diagnostic value of optical densitometry in KC.
METHODS: This cross-sectional study included 436 eyes of 295 patients with KC. Corneal optical densitometry, morphological parameters and biomechanical parameters were measured. Spearman\'s correlation analysis was employed to investigate the association between optical densitometry and both biomechanical and morphological parameters.
RESULTS: Optical densitometry of the anterior (0-2 mm and 2-6 mm), central (0-2 mm), posterior (2-6 mm) and total (2-6 mm) layers correlated positively with SPA1, while the posterior layer (0-2 mm) correlated negatively. Optical densitometry of the anterior layers 2-6 mm, 6-10 mm, and the central layer 6-10 mm negatively affected AL1, while the posterior layer 0-2 mm positively affected it. Optical densitometry of the anterior, central, and posterior layers 0-2 mm and 2-6 mm positively influenced the morphological parameters K1F, K2F, KmF and the absolute values of K1B, K2B, KmB. Optical densitometry of the center (0-2 mm) and posterior (2-6 mm) layers negatively influenced TCT. Optical densitometry of the anterior (0-2 mm and 2-6 mm), center (0-2 mm), posterior (2-6 mm) and total (2-6 mm) layers correlated positively with ACE and PCE, whereas the posterior layer (0-2 mm) correlated negatively.
CONCLUSIONS: Optical densitometry was correlated with biomechanical and morphological parameters in keratoconus, suggesting its potential as a diagnostic indicator for assessing keratoconus progression and treatment efficacy.