PDF(Pubmed)
Abstract：
BACKGROUND: Transcranial alternating current stimulation (tACS) is a prominent non-invasive brain stimulation method for modulating neural oscillations and enhancing human cognitive function. This study aimed to investigate the effects of individualized theta tACS delivered in-phase and out-of-phase between the dorsal anterior cingulate cortex (dACC) and left dorsolateral prefrontal cortex (lDLPFC) during inhibitory control performance.
METHODS: The participants engaged in a Stroop task with phase-lagged theta tACS over individually optimized high-density electrode montages targeting the dACC and lDLPFC. We analyzed task performance, event-related potentials, and prestimulus electroencephalographic theta and alpha power.
RESULTS: We observed significantly reduced reaction times following out-of-phase tACS, accompanied by reduced frontocentral N1 and N2 amplitudes, enhanced parieto-occipital P1 amplitudes, and pronounced frontocentral late sustained potentials. Out-of-phase stimulation also resulted in significantly higher prestimulus frontocentral theta and alpha activity.
CONCLUSIONS: These findings suggest that out-of-phase theta tACS potently modulates top-down inhibitory control, supporting the feasibility of phase-lagged tACS to enhance inhibitory control performance.
METHODS: The participants engaged in a Stroop task with phase-lagged theta tACS over individually optimized high-density electrode montages targeting the dACC and lDLPFC. We analyzed task performance, event-related potentials, and prestimulus electroencephalographic theta and alpha power.
RESULTS: We observed significantly reduced reaction times following out-of-phase tACS, accompanied by reduced frontocentral N1 and N2 amplitudes, enhanced parieto-occipital P1 amplitudes, and pronounced frontocentral late sustained potentials. Out-of-phase stimulation also resulted in significantly higher prestimulus frontocentral theta and alpha activity.
CONCLUSIONS: These findings suggest that out-of-phase theta tACS potently modulates top-down inhibitory control, supporting the feasibility of phase-lagged tACS to enhance inhibitory control performance.
摘要：
背景：经颅交流电刺激（tACS）是一种用于调节神经振荡和增强人类认知功能的突出的非侵入性脑刺激方法。这项研究旨在研究在抑制控制表现期间，背侧前扣带皮质（dACC）和左背外侧前额叶皮质（lDLPFC）之间的个性化thetatACS同相和异相传递的影响。
方法：参与者在针对dACC和lDLPFC的单独优化的高密度电极蒙太奇上进行了具有相位滞后thetatACS的Stroop任务。我们分析了任务性能，事件相关电位,以及脑电图θ和α功率。
结果：我们观察到异相tACS后反应时间显着减少，伴有额中央N1和N2振幅降低，顶枕骨P1振幅增强，和明显的前部中央晚期持续潜力。异相刺激还导致明显更高的前刺激额中央θ和α活性。
结论：这些发现表明，异相thetatACS有效调节自上而下的抑制控制，支持相位滞后tACS增强抑制控制性能的可行性。
方法：参与者在针对dACC和lDLPFC的单独优化的高密度电极蒙太奇上进行了具有相位滞后thetatACS的Stroop任务。我们分析了任务性能，事件相关电位,以及脑电图θ和α功率。
结果：我们观察到异相tACS后反应时间显着减少，伴有额中央N1和N2振幅降低，顶枕骨P1振幅增强，和明显的前部中央晚期持续潜力。异相刺激还导致明显更高的前刺激额中央θ和α活性。
结论：这些发现表明，异相thetatACS有效调节自上而下的抑制控制，支持相位滞后tACS增强抑制控制性能的可行性。
