■间歇性θ爆发刺激(iTBS)已证明对认知障碍患者有效。然而,iTBS对卒中后认知障碍(PSCI)的激活模式和机制尚不清楚.
■探讨PSCI患者使用iTBS的激活模式和潜在益处。
■总共纳入了44例PSCI患者,并将其分为iTBS组(iTBS和认知训练)或对照组(仅认知训练)。结果是根据功能近红外光谱(fNIRS)的激活进行评估,以及Loewenstein职业治疗认知评估(LOTCA)和改良的Barthel指数(MBI)。
■38名患者完成了干预和评估。干预后,iTBS组的皮层激活增加,包括右颞上回(STG),左额极皮质(FPC)和左眶额皮质(OFC)。干预后两组患者的LOTCA和MBI均有显著改善(p<0.05)。此外,与对照组相比,iTBS组增加了MBI和LOTCA总分的改善,尤其是在视觉运动组织和思维操作方面(p<0.05)。
■iTBS改变了PSCI患者的激活模式并改善了认知功能。iTBS诱导的激活可能有助于认知功能的改善。
UNASSIGNED: Intermittent theta burst stimulation (iTBS) has demonstrated efficacy in patients with cognitive impairment. However, activation patterns and mechanisms of iTBS for post-stroke cognitive impairment (PSCI) remain insufficiently understood.
UNASSIGNED: To investigate the activation patterns and potential benefits of using iTBS in patients with PSCI.
UNASSIGNED: A total of forty-four patients with PSCI were enrolled and divided into an iTBS group (iTBS and cognitive training) or a control group (cognitive training alone). Outcomes were assessed based on the activation in functional near-infrared spectroscopy (fNIRS), as well as Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) and the modified Barthel Index (MBI).
UNASSIGNED: Thirty-eight patients completed the interventions and assessments. Increased cortical activation was observed in the iTBS group after the interventions, including the right superior temporal gyrus (STG), left frontopolar cortex (FPC) and left orbitofrontal cortex (OFC). Both groups showed significant improvements in LOTCA and MBI after the interventions (p < 0.05). Furthermore, the iTBS group augmented superior improvement in the total score of MBI and LOTCA compared to the control group, especially in visuomotor organization and thinking operations (p < 0.05).
UNASSIGNED: iTBS altered activation patterns and improved cognitive function in patients with PSCI. The activation induced by iTBS may contribute to the improvement of cognitive function.