Abstract：
UNASSIGNED: An imbalance of excitatory and inhibitory synaptic transmission in multiple sclerosis (MS) may lead to cognitive impairment, such as impaired working memory. The 1/f slope of electroencephalography/magnetoencephalography (EEG/MEG) power spectra is shown to be a non-invasive proxy of excitation/inhibition balance. A flatter slope is associated with higher excitation/lower inhibition.
UNASSIGNED: To assess the 1/f slope modulation induced by stimulus and its association with behavioral and cognitive measures.
UNASSIGNED: We analyzed MEG recordings of 38 healthy controls (HCs) and 79 people with multiple sclerosis (pwMS) while performing an n-back task including target and distractor stimuli. Target trials require an answer, while distractor trials do not. We computed the 1/f spectral slope through the fitting oscillations and one over f (FOOOF) algorithm within the time windows 1 second before and after each stimulus presentation.
UNASSIGNED: We observed a flatter 1/f slope after distractor stimuli in pwMS compared to HCs. The 1/f slope was significantly steeper after stimulus for both HCs and pwMS and was significantly correlated with reaction times. This modulation in 1/f slope was significantly correlated with visuospatial memory assessed by the BVMT-R test.
UNASSIGNED: Our results suggest possible inhibitory mechanism deficits in pwMS during a working memory task.
UNASSIGNED: To assess the 1/f slope modulation induced by stimulus and its association with behavioral and cognitive measures.
UNASSIGNED: We analyzed MEG recordings of 38 healthy controls (HCs) and 79 people with multiple sclerosis (pwMS) while performing an n-back task including target and distractor stimuli. Target trials require an answer, while distractor trials do not. We computed the 1/f spectral slope through the fitting oscillations and one over f (FOOOF) algorithm within the time windows 1 second before and after each stimulus presentation.
UNASSIGNED: We observed a flatter 1/f slope after distractor stimuli in pwMS compared to HCs. The 1/f slope was significantly steeper after stimulus for both HCs and pwMS and was significantly correlated with reaction times. This modulation in 1/f slope was significantly correlated with visuospatial memory assessed by the BVMT-R test.
UNASSIGNED: Our results suggest possible inhibitory mechanism deficits in pwMS during a working memory task.
摘要：
■多发性硬化症（MS）中兴奋性和抑制性突触传递的失衡可能导致认知障碍，比如工作记忆受损。脑电图/脑磁图（EEG/MEG）功率谱的1/f斜率显示为激发/抑制平衡的非侵入性代表。更平坦的斜率与更高的激励/更低的抑制相关联。
■评估由刺激引起的1/f斜率调制及其与行为和认知措施的关联。
■我们分析了38名健康对照（HCs）和79名多发性硬化症（pwMS）患者的MEG记录，同时执行包括目标和干扰刺激的n-back任务。目标试验需要答案，而分心试验没有。我们在每次刺激呈现之前和之后的1秒内，通过拟合振荡和一个过f（FOOOF）算法计算了1/f频谱斜率。
■与HC相比，我们观察到pwMS中的分心刺激后的1/f斜率更平坦。对HC和pwMS均刺激后，1/f斜率显着升高，并且与反应时间显着相关。1/f斜率的这种调节与BVMT-R测试评估的视觉空间记忆显着相关。
■我们的结果表明，在工作记忆任务期间，pwMS可能存在抑制机制缺陷。
■评估由刺激引起的1/f斜率调制及其与行为和认知措施的关联。
■我们分析了38名健康对照（HCs）和79名多发性硬化症（pwMS）患者的MEG记录，同时执行包括目标和干扰刺激的n-back任务。目标试验需要答案，而分心试验没有。我们在每次刺激呈现之前和之后的1秒内，通过拟合振荡和一个过f（FOOOF）算法计算了1/f频谱斜率。
■与HC相比，我们观察到pwMS中的分心刺激后的1/f斜率更平坦。对HC和pwMS均刺激后，1/f斜率显着升高，并且与反应时间显着相关。1/f斜率的这种调节与BVMT-R测试评估的视觉空间记忆显着相关。
■我们的结果表明，在工作记忆任务期间，pwMS可能存在抑制机制缺陷。
