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Abstract：
This paper retrospectively analysed the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) in some parts of China. Between January 2013 and December 2019, we collected 4,145 respiratory samples, including pharyngeal swabs and alveolar lavage fluid. The highest PCR-positive rate of M. pneumoniae was 74.5% in Beijing, the highest resistance rate was 100% in Shanghai, and Gansu was the lowest with 20%. The highest PCR-positive rate of M. pneumoniae was 74.5% in 2013, and the highest MRMP was 97.4% in 2019; the PCR-positive rate of M. pneumoniae for adults in Beijing was 17.9% and the MRMP was 10.48%. Among the children diagnosed with community-acquired pneumonia (CAP), the PCR-positive and macrolide-resistant rates of M. pneumoniae were both higher in the severe ones. A2063G in domain V of 23S rRNA was the major macrolide-resistant mutation, accounting for more than 90%. The MIC values of all MRMP to erythromycin and azithromycin were ≥ 64 μg/ml, and the MICs of tetracycline and levofloxacin were ≤ 0.5 μg/ml and ≤ 1 μg/ml, respectively. The macrolide resistance varied in different regions and years. Among inpatients, the macrolide-resistant rate was higher in severe pneumonia. A2063G was the common mutation, and we found no resistance to tetracycline and levofloxacin.
摘要：
本文对我国部分地区大环内酯类药物耐药肺炎支原体(MRMP)的流行情况进行回顾性分析。在2013年1月至2019年12月期间，我们收集了4,145个呼吸道样本，包括咽拭子和肺泡灌洗液。北京肺炎支原体PCR阳性率最高，为74.5%，上海的耐药率最高，为100%，甘肃最低，为20%。2013年肺炎支原体PCR阳性率最高为74.5%，2019年MRMP最高为97.4%；北京地区成人肺炎支原体PCR阳性率为17.9%，MRMP为10.48%。在被诊断为社区获得性肺炎（CAP）的儿童中，重症肺炎支原体的PCR阳性和大环内酯耐药率均较高。23SrRNA的结构域V中的A2063G是主要的大环内酯抗性突变，占90%以上。所有MRMP对红霉素和阿奇霉素的MIC值≥64μg/ml,四环素和左氧氟沙星的MIC分别为≤0.5μg/ml和≤1μg/ml，分别。大环内酯抗性在不同地区和年份有所不同。在住院病人中,重症肺炎的大环内酯耐药率较高.A2063G是常见的突变，我们没有发现对四环素和左氧氟沙星的耐药性.
