{Reference Type}: Journal Article
{Title}: Macrolide resistance of Mycoplasma pneumoniae in several regions of China from 2013 to 2019.
{Author}: Jiang Y;Dou H;Xu B;Xu B;Zhou W;Wang H;Ge L;Hu Y;Han X;Qin X;Li J;Ye L;Wu L;Zuo H;Zhang Q;Liu L;Hu W;Shao J;Yin Q;Han L;Fu X;Dong X;Dong Y;Fu Y;Zhao M;Sun Q;Huo J;Liu D;Liu W;Li Y;Wang Y;Xin D;Shen K;
{Journal}: Epidemiol Infect
{Volume}: 152
{Issue}: 0
{Year}: 2024 Apr 18
{Factor}: 4.434
{DOI}: 10.1017/S0950268824000323
{Abstract}: This paper retrospectively analysed the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) in some parts of China. Between January 2013 and December 2019, we collected 4,145 respiratory samples, including pharyngeal swabs and alveolar lavage fluid. The highest PCR-positive rate of M. pneumoniae was 74.5% in Beijing, the highest resistance rate was 100% in Shanghai, and Gansu was the lowest with 20%. The highest PCR-positive rate of M. pneumoniae was 74.5% in 2013, and the highest MRMP was 97.4% in 2019; the PCR-positive rate of M. pneumoniae for adults in Beijing was 17.9% and the MRMP was 10.48%. Among the children diagnosed with community-acquired pneumonia (CAP), the PCR-positive and macrolide-resistant rates of M. pneumoniae were both higher in the severe ones. A2063G in domain V of 23S rRNA was the major macrolide-resistant mutation, accounting for more than 90%. The MIC values of all MRMP to erythromycin and azithromycin were ≥ 64 μg/ml, and the MICs of tetracycline and levofloxacin were ≤ 0.5 μg/ml and ≤ 1 μg/ml, respectively. The macrolide resistance varied in different regions and years. Among inpatients, the macrolide-resistant rate was higher in severe pneumonia. A2063G was the common mutation, and we found no resistance to tetracycline and levofloxacin.