使用转基因小鼠了解肠道微生物组上宿主异源生物感知核受体 PXR 和 CAR 的生理功能。
关键词: BA, bile acid BSH, bile salt hydrolase Bile acids CA, cholic acid CAR CAR, constitutive androstane receptor CDCA, chenodeoxycholic acid CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime CV, conventional CYP, cytochrome P450 DCA, deoxycholic acid EGF, epidermal growth factor Feces GF, germ free GLP-1, glucagon-like peptide-1 GM-CSF, granulocyte-macrophage colony-stimulating factor Gut microbiome HDCA, hyodeoxycholic acid IBD, inflammatory bowel disease IFNγ, interferon-gamma IL, interleukin IS, internal standards Inflammation LCA, lithocholic acid LC–MS/MS, liquid chromatography–tandem mass spectrometry MCA, muricholic acid MCP-1, monocyte chemoattractant protein-1 Mice NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NSAID, non-steroidal anti-inflammatory drug Nuclear receptor OH, hydroxylated OTUs, operational taxonomy units PA, indole-3 propionic acid PBDEs, polybrominated diphenyl ethers PCBs, polychlorinated biphenyls PCoA, Principle Coordinate Analysis PXR PXR, pregnane X receptor PiCRUSt, Phylogenetic Investigation of Communities by Reconstruction of Observed States QIIME, Quantitative Insights Into Microbial Ecology SCFAs, short-chain fatty acids SNP, single-nucleotide polymorphism SPF, specific-pathogen-free T, wild type T-, taurine conjugated TCPOBOP, 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene TGR-5, Takeda G-protein-coupled receptor 5 TLR4, toll-like receptor 4 TNF, tumor necrosis factor UDCA, ursodeoxycholic acid YAP, yes-associated protein hPXR-TG, humanized PXR transgenic
来 源:
DOI:10.1016/j.apsb.2021.07.022
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