基于 FeS 的自组装级联生物反应器 , 具有增强的肿瘤渗透和协同治疗 , 以触发强大的癌症免疫疗法。
关键词: ALP, alkaline phosphatise ALT, alanine transaminase AST, aspartate aminotransferase ATP, adenosine triphosphate BUN, blood urea nitrogen CDT, chemodynamic therapy CLSM, confocal laser scanning microscope CREA, creatinine CRT, calreticulin CTLA-4, cytotoxic T-lymphocyte-associated protein 4 CTLs, cytotoxic T lymphocytes Cancer immunotherapy Ce6, Chlorin e6 DAMPs, damage-related molecular patterns DAPI, 2-(4-amidinophenyl)-6-indolecarbamidine dihydrochloride DCs, dendritic cells DLS, dynamic light scattering DMPO, dimethyl pyridine N-oxide EDC, 1-ethyl-3-(3ʹ-dimethylaminopropyl) carbodiimide EDS, energy-dispersive spectrometry EPR, enhanced permeability and retention ESR, electron spin resonance FG, FeS-GOx nanodots FGP, FeS-GOx@PTX nanoparticles FITC, fluorescein Isothiocyanate FeCl2·4H2O, iron dichloride tetrahydrate FeS-based cascade bioreactor GOx, glucose oxidase Glu, glucose Glucose oxidase H&E, hematoxylin and eosin H2DCFDA, 2,7-dichlorodihydrofluorescein acetoacetic acid HMGB-1, high mobility group box protein 1 HPF, 2-[6-(4,-hydroxy) phenoxy-3H-xanthene-3-on-9-yl HSA, human serum albumin ICB, immune checkpoint blockade ICD amplifier ICD, immunogenic cell death IFN-γ, interferon-γ MB, methylene blue MCTS, multicellular tumor spheroids MFI, median fluorescence Intensity Metastasis inhibition NHS, N-hydroxy succinimide Na2S, sodium sulfide OH, hydroxyl PBS, phosphate buffer saline PTT, photothermal therapy PTX, paclitaxel ROS, reactive oxygen species SEM, scanning electron microscope Synergistic therapy TAA, tumor-associated antigens TDLN, tumor-draining lymph nodes TEM, transmission microscope TMB, 3,3ʹ,5,5ʹ-tetramathylbenzidine TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labelling Tumor penetration XPS, X-ray photoelectron spectroscopy XRD, X-ray diffraction patterns
来 源:
DOI:10.1016/j.apsb.2021.05.005
PDF(Sci-hub)
PDF(Pubmed)