■回顾文献,并提供有关活性氧(ROS)在男性不育中的作用的最新摘要。
■对PubMed的评论,Cochrane评论,和WebofScience数据库,用于1943年至2017年之间发表的全文英文文章,专注于ROS的病因,ROS对精子功能的生理作用,ROS在不孕症中的病理作用,ROS的评估,以及抗氧化剂在氧化应激中的作用。
■ROS在精子功能和受精中起作用。文献描述了ROS在生育中的生理和病理作用。生理活性所必需的ROS与保护免受细胞氧化损伤的抗氧化剂之间的微妙平衡对于生育能力至关重要。
■尽管升高的ROS水平与不孕症有关,在选择患者进行ROS测试方面没有达成共识,要执行哪个测试,或者ROS的治疗是否会对不育率和妊娠产生积极影响。
UNASSIGNED: To review the literature and provide an updated summary on the role of reactive oxygen species (ROS) in male infertility.
UNASSIGNED: A review of PubMed, Cochrane review, and Web of Science databases for full-text English-language articles published between 1943 and 2017 was performed, focusing on the aetiology of ROS, physiological role of ROS on spermatic function, pathological role of ROS in infertility, evaluation of ROS, and role of antioxidants in oxidative stress.
UNASSIGNED: ROS play a role in spermatic function and fertilisation. The literature describes both a physiological and a pathological role of ROS in fertility. A delicate balance between ROS necessary for physiological activity and antioxidants to protect from cellular oxidative injury is essential for fertility.
UNASSIGNED: Although elevated levels of ROS are implicated as a cause of infertility, there is no consensus on selecting patients to test for ROS, which test to perform, or if treatment for ROS can have a positive impact on infertility rates and pregnancy.