未经评估:本研究计划评估肱三头肌皮褶厚度(TSFT),中臂肌围(MAMC)和生物电阻抗分析(BIA),用于使用双能X射线吸收法(DEXA)(参考)评估身体成分,并预测脂肪量(FM)和无脂肪量(FFM)肝硬化患者。
未经评估:使用DEXA和BIA评估FM和FFM。皮肤褶皱卡尺用于测量TSFT,并计算了MAMC。Bland-Altman图用于确定一致性和线性回归分析,以获得预测FM和FFM的方程。
未经证实:肝硬化患者(n=302,241名男性,年龄43.7±12.0岁)。Bland-Altman图显示,BIA和DEXA在估算FM和FFM方面非常吻合。大多数患者在协议范围内:FM(98%)和FFM(96.4%)。BIA与DEXA:FM(r=0.73,P≤0.001)和FFM(r=0.86,P≤0.001)呈正相关。DEXA(FM和FFM)与TSFT(r=0.69,P≤0.01)和MAMC(r=0.61,P≤0.01)呈正相关。BIA在发育集中的FM和FFM的观察值与预测值之间的平均差分别为0.01和0.05;而在验证集中,分别为-0.13和0.86。TSFT和MAMC在发育集中的观察值和预测值之间的平均差异为0.43和0.07;然而,在验证集中,分别为0.16和0.48。
UNASSIGNED:人体测量法(TSFT和MAMC)和BIA简单易用,可替代DEXA用于肝硬化患者的常规临床设置中的FM和FFM评估。
UNASSIGNED: This study was planned to evaluate triceps skinfold thickness (TSFT), mid-arm muscle circumference (MAMC) and bioelectrical impedance analysis (BIA) for assessing body composition using dual-energy X-ray absorptiometry (DEXA) (reference) and to predict fat mass (FM) and fat-free mass (FFM) in patients with cirrhosis.
UNASSIGNED: FM and FFM were assessed by using DEXA and BIA. Skin-fold calliper was used for measuring TSFT, and MAMC was calculated. Bland-Altman plot was used to determine agreement and linear regression analysis for obtaining equations to predict FM and FFM.
UNASSIGNED: Patients with cirrhosis (n = 302, 241 male, age 43.7 ± 12.0 years) were included. Bland-Altman plot showed very good agreement between BIA and DEXA for the estimation of FM and FFM. Majority of patients were within the limit of agreement: FM (98%) and FFM (96.4%). BIA shows a positive correlation with DEXA:FM (r = 0.73, P ≤ 0.001) and FFM (r = 0.86, P ≤ 0.001). DEXA (FM and FFM) shows a positive correlation with TSFT (r = 0.69, P ≤ 0.01) and MAMC (r = 0.61, P ≤ 0.01). The mean difference between the observed and predicted value of FM and FFM by BIA in the developmental set was 0.01 and 0.05, respectively; whereas in the validation set, it was -0.13 and 0.86, respectively. The mean difference between the observed and predicted value of TSFT and MAMC in the developmental set was 0.43 and 0.07; whereas, in the validation set, it was 0.16 and 0.48, respectively.
UNASSIGNED: Anthropometry (TSFT and MAMC) and BIA are simple and easy to use and can be a substitute of DEXA for FM and FFM assessment in routine clinical settings in patients with cirrhosis.