使用基于人原代细胞的快速疾病筛查模型 ,将下一代产品与可燃香烟进行比较。
关键词: ACM, aerosol collected mass AhR, Aryl hydrocarbon receptor Alternative methods COPD, Chronic obstructive pulmonary disease EGFR, epidermal growth factor receptor ELISA, enzyme-linked immunosorbent assay EVP, Electronic vapor product HDFn, Human neonatal dermal fibroblasts HTP, Heated Tobacco Product HUVEC, Human umbilical vein endothelial cells HYB, Hybrid product containing e-liquid drawn through a tobacco plug IL, interleukin ISO, International Organization for Standardization In vitro assays MOA, Mechanism of action M−CSF, Macrophage colony-stimulating factor NGP, Next generation product NRC, National Research Council NRF2, Nuclear factor erythroid 2-related factor 2 Next generation products PBMC, Peripheral blood mononuclear cells PBS, Phosphate buffered saline Panel Phenotypic screening SRB, Sulforhodamine B TCR, T cell receptor TF, Tissue factor TLR, toll-like receptor TNFα, tumor necrosis factor alpha TPM, Total particulate matter Toxicity signature bPBS, Bubbled phosphate buffered saline mTOR, mechanistic target of rapamycin
来 源:
DOI:10.1016/j.crtox.2021.08.003
PDF(Sci-hub)
PDF(Pubmed)