Abstract:
Inhibitory control deficit and impulsivity and compulsivity behaviours are present in different psychopathological disorders such as addiction, obsessive-compulsive disorders and schizophrenia, among others. Social relationships in humans and animals are governed by social organization rules, which modulate inhibitory control and coping strategies against stress. Social stress is associated with compulsive alcohol and drug use, pointing towards a determining factor in an increased vulnerability to inhibitory control deficit. The goal of the present review is to assess the implication of social stress and dominance on the vulnerability to develop impulsive and/or compulsive spectrum disorders, with the aid of the information provided by animal models. A systematic search strategy was carried out on the PubMed and Web of Science databases, and the most relevant information was structured in the text and tables. A total of 34 studies were recruited in the qualitative synthesis. The results show the role of social stress and dominance in increased drug and alcohol use, aggressive and impulsive behaviour. Moreover, the revised studies support the role of Dopaminergic (DA) activity and the alterations in the dopaminergic D1/D2 receptors as key factors in the development of inhibitory control deficit by social stress.
摘要:
抑制性控制缺陷和冲动和强迫行为存在于不同的精神病理学障碍,如成瘾,强迫症和精神分裂症,在其他人中。人类和动物的社会关系受社会组织规则的支配,调节抑制控制和应对压力的策略。社会压力与强迫性饮酒和吸毒有关,指出抑制控制缺陷脆弱性增加的决定性因素。本综述的目的是评估社会压力和支配地位对发展冲动和/或强迫性谱系障碍的脆弱性的影响。借助动物模型提供的信息。在PubMed和WebofScience数据库上进行了系统的搜索策略,最相关的信息在文本和表格中进行了结构化。在定性综合中总共招募了34项研究。结果表明,社会压力和主导地位在增加药物和酒精使用中的作用,攻击性和冲动行为。此外,修订后的研究支持多巴胺能(DA)活性的作用以及多巴胺能D1/D2受体的改变是社会压力导致抑制性控制缺陷发展的关键因素。