背景:2型糖尿病是全球范围内最普遍和可预防的疾病之一,一种心理特征,其特征是在没有深思熟虑的情况下做出快速决定,已被建议作为健康相关疾病的关键特征。然而,目前还没有研究探讨冲动性与2型糖尿病发病率之间的关系,我们的目的是评估特质冲动性与2型糖尿病发病风险之间的前瞻性关联.
方法:2014年5月至2023年2月在NutriNet-Santé队列中进行了前瞻性观察性研究设计。一个基于网络的平台被用来收集法国成年人的数据,自愿注册和参与。在评估冲动性时,参加NutriNet-Santé研究的157,591名成年人(≥18岁)中,109,214名参与者由于流行的1型或2型糖尿病或2型糖尿病的冲动或随访数据缺失而被排除。特质冲动,和注意力,电机,和非计划子因素,在基线时使用Barratt冲动性量表11进行评估。通过随访确定发生2型糖尿病。NutriNet-Santé医师专家对医疗信息进行了审查,以根据ICD-10确定糖尿病事件。Cox回归模型,使用风险比和95%置信区间(HR[95%CI]),进行评估每1个标准差增量的冲动性与2型糖尿病风险之间的关联,通过公认的混杂因素进行调整。
结果:在研究的48,377名个体中(女性77.6%;基线年龄=50.6岁±14.5岁),556名患者在平均随访7.78年(IQR:3.97-8.49年)期间发展为2型糖尿病。基线冲动与2型糖尿病发病风险增加相关(HR=1.10[1.02,1.20])。运动冲动子因子与2型糖尿病风险呈正相关(HR=1.14[1.04,1.24]),而没有发现注意力和非计划冲动性子因素的关联。
结论:特质冲动与2型糖尿病风险增加有关,主要由电机冲动性子因素驱动。如果这些结果在其他人群和环境中复制,特质冲动可能成为预防2型糖尿病的重要心理危险因素。
■注册名称:NutriNet-Santé研究。基于Web的前瞻性队列研究,研究营养与健康之间的关系以及饮食模式和营养状况预测因子。队列注册号:NCT03335644。注册日期:2017年10月11日。URL:https://clinicaltrials.gov/ct2/show/NCT03335644。
BACKGROUND: Type 2 diabetes is one of the most prevalent and preventable diseases worldwide and
impulsivity, a psychological trait characterized by making quick decisions without forethought, has been suggested as a key feature for health-related conditions. However, there have been no studies examining the relationships between
impulsivity and the incidence of type 2 diabetes and our aim was to assess the prospective association between trait
impulsivity and the risk of developing type 2 diabetes.
METHODS: A prospective observational study design was conducted between May 2014 and February 2023 within the NutriNet-Santé cohort. A web-based platform was used to collect data from the French adult population, with voluntary enrollment and participation. Of the 157,591 adults (≥ 18 years old) participating in the NutriNet-Santé study when
impulsivity was assessed, 109,214 participants were excluded due to prevalent type 1 or 2 diabetes or missing data for impulsivity or follow-up data for type 2 diabetes. Trait impulsivity, and the attention, motor, and non-planning subfactors, were assessed at baseline using the Barratt Impulsiveness Scale 11. Incident type 2 diabetes was ascertained through follow-up. Medical information was reviewed by NutriNet-Santé physician experts to ascertain incident diabetes cases based on the ICD-10. Cox regression models, using hazard ratios and 95% confidence intervals (HR [95% CI]), were performed to evaluate associations between impulsivity per 1 standard deviation increment and type 2 diabetes risk, adjusting by recognized confounders.
RESULTS: Of the 48,377 individuals studied (women 77.6%; age at baseline = 50.6 year ± 14.5 years), 556 individuals developed type 2 diabetes over a median follow-up of 7.78 (IQR: 3.97-8.49) years. Baseline impulsivity was associated with an increased risk of type 2 diabetes incidence (HR = 1.10 [1.02, 1.20]). The motor impulsivity subfactor was positively associated with type 2 diabetes risk (HR = 1.14 [1.04, 1.24]), whereas no associations were found for attention and non-planning impulsivity subfactors.
CONCLUSIONS: Trait impulsivity was associated with an increased type 2 diabetes risk, mainly driven by the motor
impulsivity subfactor. If these results are replicated in other populations and settings, trait impulsivity may become an important psychological risk factor to be considered in the prevention of type 2 diabetes.
UNASSIGNED: Name of registry: The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors. Cohort registration number: NCT03335644. Date of registration: October 11, 2017. URL: https://clinicaltrials.gov/ct2/show/NCT03335644.