对损伤的免疫反应及其与眼病的联系。
关键词: 2ryERM A T-helper cell that expresses high levels of IL-17 which can suppress T-regulatory cell function A cytokine expressed early during inflammation that attracts neutrophils A cytokine expressed early during inflammation that attracts neutrophils, sometimes referred to as monocyte chemoattractant protein-1 (MCP-1)) A mouse model that lacks functional T and B cells and used to study the immune response A pigmented mouse strain used for research and known to mount a primarily Th1 response to infection A protein encoded by the ADGRE1 gene that, in mice, is expressed primarily on macrophages A strain of pigmented mice used in glaucoma research ACAID APCs ASC An albino mouse strain used for research and known to mount a primarily Th2 response to infection Antigen Presenting Cells, this class includes dendritic cells and monocytes BALB/c BM C57BL6 CCL2 CD45 CNS CXCL1 Central Nervous System Cluster of differentiation 45 antigen DAMPs DBA/2J EBM ECM EMT ERM Epithelial Basement Membrane F4/80 FGF2 HA =hyaluronic acid HSK HSP HSPGs HSV ICN IL-20 IL6 ILM IOP Inner (or internal) limiting membrane Interleukin 6 Interleukin-20 MAGP1 MHC-II Major histocompatibility complex type II, a class of MHC proteins typically found only on APCs Microfibril-associated glycoprotein 1 N-cad N-cadherin NEI NK National Eye Institute Natural killer T cells PCO PDGF PDR PVD PVR Platelet derived growth factor Posterior capsular opacification RGC RPE RRD Rag1-/- Retinal ganglion cells Retinal pigment epithelial cells SMAD Sons of Mothers Against Decapentaplegic, SMADs are a class of molecules that mediate TGF and bone morphogenetic protein signaling T-helper cell 1 response, proinflammatory adaptive response involving interferon gamma and associated with autoimmunity T-helper cell 2 response involving IgE and interleukins 4,5, and 13, also induces the anti-inflammatory interleukin 10 family cytokines T-regulatory cell TG TGF1 TM TNF Th1 Th17 Th2 Transforming growth factor 1 Treg Tumor necrosis factor a cytokine produced during inflammation VEGF Vascular endothelial growth factor WHO World Health Organization anterior chamber immune deviation anterior subcapsular cataracts basement membrane damage-associated molecular patterns epiretinal membrane epiretinal membrane secondary to disease pathology epithelial-mesenchymal transition extracellular matrix fibroblast growth factor 2, also referred to as basic FGF heat shock protein heparan sulfate proteoglycans herpes simplex virus herpes stromal keratitis iERM idiopathic epiretinal membrane intraepithelial corneal nerves intraocular pressure mTOR mechanistic target of rapamycin, a protein kinase encoded by the MTOR genes that regulates a variety of signal transduction events including cell growth, autophagy and actin cytoskeleton posterior vitreous detachment proliferative diabetic retinopathy proliferative vitreoretinopathy rhegmatogenous (rupture, tear) retinal detachment trabecular meshwork trigeminal ganglion αSMA α−Smooth muscle actin, a class of actin expressed in mesenchymal cells
Mesh : Eye Injuries / immunology pathology Fibrosis Humans Immunity Inflammation / pathology Lens, Crystalline / pathology
来 源:
DOI:10.1016/j.trsl.2021.05.005
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