眼睛被视为免疫特权位点。因为脉管系统的存在会损害视力,眼睛的脉管系统位于中心光路之外。因此,眼睛的许多区域进化了将免疫细胞传递到发育不全部位的机制,损伤,或对许多与年龄有关的疾病的反应。虽然这些免疫反应的目的是修复性或保护性的,免疫细胞释放的细胞因子通过诱导炎症和纤维化损害视力。对创伤性或病理性损伤的反应在眼睛的不同区域是不同的。与年龄有关的疾病会影响前段和后段,并导致生活质量下降和失明。在这里,我们将注意力集中在炎症和纤维化在角膜和晶状体以及青光眼的年龄相关性病变进展中的作用。视网膜前膜的形成,和增生性玻璃体视网膜病变。
The eye is regarded as an immune privileged site. Since the presence of a vasculature would impair vision, the vasculature of the eye is located outside of the central light path. As a result, many regions of the eye evolved mechanisms to deliver immune cells to sites of dysgenesis, injury, or in response to the many age-related pathologies. While the purpose of these immune responses is reparative or protective, cytokines released by immune cells compromise visual acuity by inducing inflammation and fibrosis. The response to traumatic or pathological injury is distinct in different regions of the eye. Age-related diseases impact both the anterior and posterior segment and lead to reduced quality of life and blindness. Here we focus attention on the role that inflammation and fibrosis play in the progression of age-related pathologies of the cornea and the lens as well as in glaucoma, the formation of epiretinal membranes, and in proliferative vitreoretinopathy.