未经授权:骨关节炎(OA)是最常见的退行性关节疾病,其病因尚不完全清楚。该研究的目的是评估白细胞介素18(IL-18)和白细胞介素20(IL-20)在膝关节OA发病机理中的参与及其与其他炎症和关节软骨破坏标志物的相关性。以及临床和放射学变化。
UNASSIGNED:该研究包括25例膝OA患者和一个对照组。IL-18、IL-20、IL-6、MMP-1、MMP-3、PG-AG,测定血清和滑液(SF)中的YKL-40。我们还根据Kellgren-Lawrence(K-L)量表评估了膝关节的放射学病变,根据西安大略省和麦克马斯特大学骨关节炎指数(WOMAC)和Lequesne指数,疾病的临床严重程度。
UNASSIGNED:OA患者血清中IL-18和IL-20的浓度明显高于对照组(106.00±189.76pg/mlvs.16.73±16.99pg/ml,p<0.001,17.69±13.45pg/ml与9.76±9.00pg/ml,p<0.014)。血清IL-18浓度与MMP-3(R=0.58;p=0.006)和YKL-40(R=0.48;p=0.002)呈正相关。OA的放射学进展程度(K-L量表)与临床评估呈正相关(WOMAC,R=0.74,p≤0.001;Lequesne指数,R=0.57,p=0.003)。
未经证实:ROC曲线分析显示IL-20与COMP、MMP-3和YKL-40可能是膝关节OA的诊断标志物。观察结果表明,IL-18可能主要在关节内过程中介导,而IL-20可能是全身性炎症反应的主要原因。
UNASSIGNED: Osteoarthritis (OA) is the most common degenerative joint disease, and its aetiology is not entirely known. The aim of the study was to evaluate the involvement of interleukin-18 (IL-18) and interleukin-20 (IL-20) in the pathogenesis of knee OA and their correlations with other markers of inflammation and destruction of joint cartilage, as well as clinical and radiological changes.
UNASSIGNED: The study included 25 patients with knee OA and a control group. The concentration of IL-18, IL-20, IL-6, MMP-1, MMP-3, COMP, PG-AG, and YKL-40 in serum and synovial fluid (SF) were determined. We also evaluated radiological lesions of the knee joint according to the Kellgren-Lawrence (K-L) scale, and clinical severity of the disease according to Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Lequesne Index.
UNASSIGNED: The concentrations of IL-18 and IL-20 were statistically significantly higher in serum of patients with OA than in the control group (106.00 ±189.76 pg/ml vs. 16.73 ±16.99 pg/ml, p < 0.001, 17.69 ±13.45 pg/ml vs. 9.76 ±9.00 pg/ml, p < 0.014). Serum concentration of IL-18 positively correlated with MMP-3 (R = 0.58; p = 0.006) and YKL-40 (R = 0.48; p = 0.002). The degree of radiological advancement of OA (K-L scale) correlated positively with clinical evaluation (WOMAC, R = 0.74, p ≤ 0.001; Lequesne Index, R = 0.57, p = 0.003).
UNASSIGNED: The analysis of ROC curves showed that IL-20 as well as COMP, MMP-3, and YKL-40 may be diagnostic markers of knee OA. The observations indicate that IL-18 potentially mediates mainly in intra-articular processes and IL-20 could be primarily responsible for the systemic inflammatory reaction.