Failure of syndromic management due to drug-resistant Mycoplasma genitalium infection in South Africa: a case report.

南非耐药生殖支原体感染导致综合征治疗失败 ： 一例病例报告。

• 影响指数: 1.456
• 发表时间: 04 2019
• 来源期刊: Int J STD AIDS
• DOI: 10.1177/0956462418820745
• PMID: 30714876
• 文章类型: Case Reports
• 中科院分区: Q4
• 方向: 医学
• 作者列表: Maduna LD,Laumen JG,Radebe O,Kock MM,Peters RP

关键词: Africa; Non-gonococcal urethritis; bacterial disease; location; men; other; treatment; urethritis (bacterial)

Mesh: Adult; Anti-Bacterial Agents / pharmacology; DNA, Bacterial / genetics; Drug Resistance, Multiple, Bacterial / genetics; Dysuria / etiology; HIV Seronegativity; Humans; Lost to Follow-Up; Macrolides / pharmacology; Male; Mycoplasma Infections / diagnosis drug therapy microbiology; Mycoplasma genitalium / drug effects genetics isolation & purification; Quinolones / pharmacology; RNA, Ribosomal, 23S / drug effects genetics; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Urethritis / etiology

Abstract

We report a case of management failure of male urethritis syndrome due to macrolide-resistant Mycoplasma genitalium in South Africa. We detected mutations in 23S rRNA and one of the quinolone resistance-determining regions. This report confirms that drug-resistant M. genitalium infection can undermine the effectiveness of syndromic management in Africa.

摘要

我们报告了南非因大环内酯耐药的生殖支原体引起的男性尿道炎综合征管理失败的案例。我们检测到23SrRNA和喹诺酮耐药决定区之一的突变。该报告证实，耐药生殖支原体感染会破坏非洲综合征管理的有效性。