{Reference Type}: Case Reports {Title}: Failure of syndromic management due to drug-resistant Mycoplasma genitalium infection in South Africa: a case report. {Author}: Maduna LD;Laumen JG;Radebe O;Kock MM;Peters RP; {Journal}: Int J STD AIDS {Volume}: 30 {Issue}: 5 {Year}: 04 2019 {Factor}: 1.456 {DOI}: 10.1177/0956462418820745 {Abstract}: We report a case of management failure of male urethritis syndrome due to macrolide-resistant Mycoplasma genitalium in South Africa. We detected mutations in 23S rRNA and one of the quinolone resistance-determining regions. This report confirms that drug-resistant M. genitalium infection can undermine the effectiveness of syndromic management in Africa.