%0 Case Reports %T Failure of syndromic management due to drug-resistant Mycoplasma genitalium infection in South Africa: a case report. %A Maduna LD %A Laumen JG %A Radebe O %A Kock MM %A Peters RP %J Int J STD AIDS %V 30 %N 5 %D 04 2019 %M 30714876 %F 1.456 %R 10.1177/0956462418820745 %X We report a case of management failure of male urethritis syndrome due to macrolide-resistant Mycoplasma genitalium in South Africa. We detected mutations in 23S rRNA and one of the quinolone resistance-determining regions. This report confirms that drug-resistant M. genitalium infection can undermine the effectiveness of syndromic management in Africa.