油菜以 IL - 12 依赖性方式增强自然杀伤活性和 IFN - γ 的产生
关键词: APCs, antigen-presenting cells BMDCs, bone marrow-derived dendritic cells BW, body weight Brassica rapa L. CFSE, carboxyfluorescein diacetate succinimidyl ester CLRs, C-type lectin receptors Con A, concanavalin A Cyto D, cytochalasin D DCs, dendritic cells EDTA, ethylenediamine-N,N,N′,N′,-tetraacetic acid ELISA, enzyme-linked immunosorbent assay ERK, extracellular signal-related kinase FBS, fetal bovine serum FITC, fluorescein isothiocyanate GM-CSF, granulocyte-macrophage colony-stimulating factor IFN, interferon IL, interleukin JNK, jun kinase LPS, lipopolysaccharide MAPK, mitogen-activated protein kinase MHC, major histocompatibility complex NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NK, natural killer PB, polymyxin B PBS, phosphate-buffered saline PE, phycoerythrin PGN, peptidoglycan PI, propidium iodide PPs, Peyer’s patches RPMI, Roswell Park Memorial Institute SD, standard deviation Syk, spleen tyrosine kinase TCR, T cell receptor TLRs, Toll-like receptors TNF, tumor necrosis factor WT, wild-type dendritic cells i.p., intraperitoneally immunomodulation interferon-γ mAbs, monoclonal antibodies mLNs, mesenteric lymph nodes natural killer cell activity
Mesh : Adjuvants, Immunologic / administration & dosage pharmacology Administration, Oral Animals Brassica rapa / metabolism Cytokines / metabolism Female Functional Food Interferon-gamma / biosynthesis Interleukin-12 / physiology Killer Cells, Natural / drug effects immunology Lectins, C-Type / metabolism Male Mice, Inbred C57BL Mitogen-Activated Protein Kinases / metabolism NF-kappa B / metabolism Plant Extracts / administration & dosage pharmacology Signal Transduction Spleen / drug effects metabolism Syk Kinase / metabolism Toll-Like Receptor 2 / metabolism Toll-Like Receptor 4 / metabolism
来 源:
DOI:10.1080/09168451.2017.1408396
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