非酒精性脂肪肝（NAFL）是一种新兴的全球流行病，在一部分受试者中发展为非酒精性脂肪性肝炎（NASH）和肝硬化。各种评论都集中在病因上，流行病学,NAFLD的发病机制和治疗。这篇综述特别突出了与从NAFL到NASH的疾病进展有关的触发因素。基因的整合作用，饮食因素，先天免疫,已经讨论了细胞因子和肠道微生物组。
Nonalcoholic fatty liver (NAFL) is an emerging global epidemic which progresses to nonalcoholic steatohepatitis (NASH) and cirrhosis in a subset of subjects. Various reviews have focused on the etiology, epidemiology, pathogenesis and treatment of NAFLD. This review highlights specifically the triggers implicated in disease progression from NAFL to NASH. The integrating role of genes, dietary factors, innate immunity, cytokines and gut microbiome have been discussed.
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