脂毒性被定义为脂质的长期代谢失衡,导致外周器官如肝脏中的异位脂肪分布。心,还有肾.心肌细胞中脂质过度积累的有害后果会导致心脏脂毒性,改变了心脏的结构和功能。肥胖和糖尿病与脂毒性心肌病有关。这些异常可能是由有害的代谢转变引起的,该代谢转变积累了有毒的脂质并将葡萄糖氧化转变为较少的脂肪酸氧化。研究已经将脂肪酸联系起来,脂酰辅酶A,二酰基甘油,和神经酰胺对细胞的脂毒性应激。这种压力可以由细胞凋亡引起,胰岛素信号受损,内质网应激,蛋白激酶C激活,p38Ras-丝裂原活化蛋白激酶(MAPK)活化,或过氧化物酶体增殖物激活受体(PPARs)家族成员的修饰。姜黄是用来提取姜黄素的,具有多种药理特性的疏水性多酚衍生物。多年来,姜黄素已经被用作消炎药,抗氧化剂,抗癌,保肝,心脏保护,抗糖尿病,和抗肥胖药物。姜黄素通过抑制细胞凋亡和降低细胞凋亡相关蛋白的表达来降低心肌脂毒性,减少炎症细胞因子的表达,激活自噬信号通路,抑制内质网应激标志物蛋白的表达。
Lipotoxicity is defined as a prolonged metabolic imbalance of lipids that results in ectopic fat distribution in peripheral organs such as the liver, heart, and kidney. The harmful consequences of excessive lipid accumulation in cardiomyocytes cause cardiac
lipotoxicity, which alters the structure and function of the heart. Obesity and diabetes are linked to lipotoxic cardiomyopathy. These anomalies might be caused by a harmful metabolic shift that accumulates toxic lipids and shifts glucose oxidation to less fatty acid oxidation. Research has linked fatty acids, fatty acyl coenzyme A, diacylglycerol, and ceramide to lipotoxic stress in cells. This stress can be brought on by apoptosis, impaired insulin signaling, endoplasmic reticulum stress, protein kinase C activation, p38 Ras-mitogen-activated protein kinase (MAPK) activation, or modification of peroxisome proliferator-activated receptors (PPARs) family members. Curcuma longa is used to extract curcumin, a hydrophobic polyphenol derivative with a variety of pharmacological characteristics. Throughout the years, curcumin has been utilized as an anti-inflammatory, antioxidant, anticancer, hepatoprotective, cardioprotective, anti-diabetic, and anti-obesity drug. Curcumin reduces cardiac
lipotoxicity by inhibiting apoptosis and decreasing the expression of apoptosis-related proteins, reducing the expression of inflammatory cytokines, activating the autophagy signaling pathway, and inhibiting the expression of endoplasmic reticulum stress marker proteins.