关键词: ADP AMPPNP AP1 ATP ATP hydrolysis Allosteric inhibition CDK1 DMSO DNA Eg5 GFP GTP ICL KHC KSP Kinesin L5 MT Mitosis NCBI NER NTP NTPases National Center for Biotechnology Information P loop P(i) PDB Protein DataBank RNAi RefSeq Reference Sequence S-trityl-l-cysteine STC Traf4 XPF Xeroderma pigmentosum group F activator protein 1 adenosine diphosphate adenosine-5′-(β,γ-imido)triphosphate adenosine-5′-triphosphate cryo-EM cryo-electron microscopy cyclin-dependent kinase 1 deoxyribonucleic acid dimethyl sulfoxide double stranded ribonucleic acid interference dsRNAi green fluorescent protein guanosine-5′-triphosphate inorganic phosphate interstrand DNA cross-linking kDa kilodalton kinesin heavy chain kinesin spindle protein loop 5 microtubule nucleotide excision repair nucleotide triphosphatases nucleotide triphosphate pN phosphate-binding loop piconewton ribonucleic acid interference siRNA small interfering ribonucleic acid tumor necrosis factor receptor associated factor 4
Mesh : Animals Antineoplastic Agents / pharmacology therapeutic use Humans Kinesins / antagonists & inhibitors genetics metabolism Mitosis / drug effects genetics Molecular Targeted Therapy / methods Phylogeny Signal Transduction / genetics physiology Spindle Apparatus / drug effects metabolism
来 源: DOI:10.1016/j.gene.2013.08.004