■自1952年寨卡病毒(ZIKV):黄病毒以来,最初是在人类中发现的,与黄病毒科的其他成员相比,它没有得到足够的科学研究;如登革病毒(DENV)。然而,这并没有阻止这种病毒感染全球人口。特别是,ZIKV的全球传播导致了观察性研究的激增.
■关于最近发表的ZIKV相关文献,我们不知道有任何从观察性研究的角度严格关注ZIKV的评论.因此,我们回顾了最近发表的观察性研究,这些研究探讨了ZIKV的全球传播及其与成人先天性ZIKV感染(CZI)和临床表现的相关性.在线数据库,包括谷歌学者,PubMed和Elsevier用于检索相关研究。
■在世界不同地区报告了ZIKV病例,某些地区报告的病例比其他地区多,比如巴西.ZIKV导致广泛的疾病和障碍,包括小头畸形,发育障碍,和格林-巴利综合征仅举几例。此外,新生儿CZI主要表现为神经系统疾病,而成人中的ZIKV靶向各种器官。
■ZIKV对人口构成严重威胁,观察性研究为ZIKV在现实生活中的破坏能力提供了不同的视角。此外,有关ZIKV相关并发症的文献中存在空白,未来的实验研究需要解决.这些并发症包括子宫内传播,格林-巴利综合征,交叉反应性,性传播,以及它在男性生殖道的持久性。
UNASSIGNED: Since 1952 when Zika Virus (ZIKV): a Flavivirus, was first discovered in humans, it has not received enough scientific research compared to some of the other members of the family Flaviviridae; like Dengue Virus (DENV). However, this has not stopped the virus from infecting the human population globally. In particular, the global spread of ZIKV has led to a surge in observational studies.
UNASSIGNED: Regarding recently published ZIKV-related literature, we are not aware of any reviews strictly focusing on ZIKV from the perspective of observational studies. Therefore, we reviewed recently published observational studies exploring the global spread of ZIKV and its association with Congenital ZIKV Infection (CZI) and clinical manifestations in adults. Online databases including google scholar, PubMed and Elsevier were used for retrieving relevant studies.
UNASSIGNED: ZIKV cases have been reported in different parts of the world, with certain regions reporting more cases than the rest, like Brazil. ZIKV causes a wide spectrum of diseases and disorders including microcephaly, developmental disorders, and Guillain-Barre syndrome to name a few. Furthermore, CZI in neonates mainly manifests into neurological disorders and diseases, whereas ZIKV in adults\' targets various organs.
UNASSIGNED: ZIKV poses a serious threat to human population and observational studies provide a different perspective on the damaging capabilities of ZIKV in real-life settings. Moreover, there are gaps in the literature regarding ZIKV-related-complications that future experimental studies need to address. These complications include in-utero transmission, Guillain-Barre syndrome, cross-reactivity, sexual transmission, along with its persistence in the male reproductive tract.