■增殖性糖尿病视网膜病变(PDR)是一种常见的糖尿病并发症,显著影响视力和生活质量。先前的研究表明,精氨酸途径代谢产物与糖尿病性视网膜病变(DR)之间存在潜在的联系。结缔组织生长因子(CTGF)在PDR患者纤维血管增生(FVP)的发生、发展中起作用。然而,PDR中精氨酸途径代谢产物与FVP之间的关系尚不明确。本研究旨在探讨四种精氨酸途径代谢产物(精氨酸,不对称二甲基精氨酸[ADMA],鸟氨酸,和瓜氨酸)和PDR患者FVP的严重程度。
■在这项研究中,分别从30例无糖尿病(DM)的年龄相关性白内障患者和85例PDR患者中收集血浆和房水样本。PDR患者根据FVP的严重程度分为轻度至中度或重度。该研究使用Kruskal-Wallis试验来比较精氨酸,ADMA,鸟氨酸,和瓜氨酸水平在三组。二元逻辑回归确定了严重PDR的危险因素。Spearman相关分析评估了血浆和房水代谢物水平之间的关联,PDR患者房水中ADMA和CTGF水平之间的关系。
■重度PDR患者房水中的ADMA水平明显高于轻度至中度PDR患者(P=0.0004)。然而,精氨酸的血浆和房水水平,鸟氨酸,和瓜氨酸在轻度至中度PDR患者和重度PDR患者之间没有显着差异(P>0.05)。二元Logistic回归分析显示,PDR患者血浆(P=0.01)和房水(P=0.006)ADMA水平是重度PDR的危险因素。此外,发现血浆和房水ADMA水平之间存在显着相关性(r=0.263,P=0.015),房水ADMA和CTGF水平之间存在显着相关性(r=0.837,P<0.001)。
■血浆和房水中ADMA水平升高与PDR中FVP的严重程度呈正相关,表明ADMA是严重PDR的危险因素。
UNASSIGNED: Proliferative diabetic retinopathy (PDR) is a common diabetes complication, significantly impacting vision and quality of life. Previous studies have suggested a potential link between arginine pathway metabolites and diabetic retinopathy (DR). Connective tissue growth factor (CTGF) plays a role in the occurrence and development of fibrovascular proliferation (FVP) in PDR patients. However, the relationship between arginine pathway metabolites and FVP in PDR remains undefined. This study aimed to explore the correlation between four arginine pathway metabolites (arginine, asymmetric dimethylarginine[ADMA], ornithine, and citrulline) and the severity of FVP in PDR patients.
UNASSIGNED: In this study, plasma and aqueous humor samples were respectively collected from 30 patients with age-related cataracts without diabetes mellitus (DM) and from 85 PDR patients. The PDR patients were categorized as mild-to-moderate or severe based on the severity of fundal FVP. The study used Kruskal-Wallis test to compare arginine, ADMA, ornithine, and citrulline levels across three groups. Binary logistic regression identified risk factors for severe PDR. Spearman correlation analysis assessed associations between plasma and aqueous humor metabolite levels, and between ADMA and CTGF levels in aqueous humor among PDR patients.
UNASSIGNED: ADMA levels in the aqueous humor were significantly greater in patients with severe PDR than in those with mild-to-moderate PDR(P=0.0004). However, the plasma and aqueous humor levels of arginine, ornithine, and citrulline did not significantly differ between mild-to-moderate PDR patients and severe PDR patients (P>0.05). Binary logistic regression analysis indicated that the plasma (P=0.01) and aqueous humor (P=0.006) ADMA levels in PDR patients were risk factors for severe PDR. Furthermore, significant correlations were found between plasma and aqueous humor ADMA levels (r=0.263, P=0.015) and between aqueous humor ADMA and CTGF levels (r=0.837, P<0.001).
UNASSIGNED: Elevated ADMA levels in plasma and aqueous humor positively correlate with the severity of FVP in PDR, indicating ADMA as a risk factor for severe PDR.