背景:轻度认知障碍(MCI)是一个重要的公共卫生问题,也是阿尔茨海默病(AD)的潜在前兆。这项研究利用电子健康记录(EHR)数据来探索MCI发病率的城乡差异。危险因素,和西密歇根的医疗保健导航。
方法:对CorewellHealthWest的1,528,464名患者进行了分析,使用2015年1月1日至2022年7月31日之间的面对面相遇。MCI病例是使用国际疾病分类(ICD)代码识别的,关注45岁以上无MCI、痴呆症、或AD诊断。发病率,累积发生率,初级保健医生(PCP),研究了农村和城市地区的神经心理学转诊结局.通过单因素和多因素Cox回归分析评估危险因素。病人数量的地理分布,医院位置,和神经内科转诊进行了检查。
结果:在423,592名患者中,与农村地区相比,城市地区的MCI发病率更高(3.83vs.3.22/1000人年)。然而,敏感性分析显示,当包括直接进展为痴呆的患者时,农村地区的发病率较高.城市患者转诊和完成神经学服务的比率更高。虽然MCI的风险因素在城市和农村人口中基本相似,MCI事件的城市特定因素是听力损失,炎症性肠病,阻塞性睡眠呼吸暂停,失眠,作为非裔美国人,体重不足。常见的危险因素包括糖尿病,颅内损伤,脑血管疾病,冠状动脉疾病,中风,帕金森病,癫痫,慢性阻塞性肺疾病,抑郁症,和年龄增加。较低的风险与女性有关,具有较高的体重指数,有较高的舒张压.
结论:这项研究强调了MCI发病率和获得护理的城乡差异,这表明农村地区的潜在诊断不足可能是由于接触专家的机会减少。未来的研究应该探索社会经济,环境,和MCI的生活方式决定因素,以完善跨地理环境的预防和管理策略。
■利用EHR探索西密歇根州MCI的城乡差异。显示MCI的严重诊断不足,尤其是在农村地区。观察到农村患者的神经系统转诊和完成率较低。确定了农村和城市人口特有的风险因素。
BACKGROUND: Mild cognitive impairment (MCI) is a significant public health concern and a potential precursor to Alzheimer\'s disease (AD). This study leverages electronic health record (EHR) data to explore rural-urban differences in MCI incidence, risk factors, and healthcare navigation in West Michigan.
METHODS: Analysis was conducted on 1,528,464 patients from Corewell Health West, using face-to-face encounters between 1/1/2015 and 7/31/2022. MCI cases were identified using International Classification of Diseases (ICD) codes, focusing on patients aged 45+ without prior MCI, dementia, or AD diagnoses. Incidence rates, cumulative incidences, primary care physicians (PCPs), and neuropsychology referral outcomes were examined across rural and urban areas. Risk factors were evaluated through univariate and multivariate Cox regression analyses. The geographic distribution of patient counts, hospital locations, and neurology department referrals were examined.
RESULTS: Among 423,592 patients, a higher MCI incidence rate was observed in urban settings compared to rural settings (3.83 vs. 3.22 per 1,000 person-years). However, sensitivity analysis revealed higher incidence rates in rural areas when including patients who progressed directly to dementia. Urban patients demonstrated higher rates of referrals to and completion of neurological services. While the risk factors for MCI were largely similar across urban and rural populations, urban-specific factors for incident MCI are hearing loss, inflammatory bowel disease, obstructive sleep apnea, insomnia, being African American, and being underweight. Common risk factors include diabetes, intracranial injury, cerebrovascular disease, coronary artery disease, stroke, Parkinson\'s disease, epilepsy, chronic obstructive pulmonary disease, depression, and increased age. Lower risk was associated with being female, having a higher body mass index, and having a higher diastolic blood pressure.
CONCLUSIONS: This study highlights rural-urban differences in MCI incidence and access to care, suggesting potential underdiagnosis in rural areas likely due to reduced access to specialists. Future research should explore socioeconomic, environmental, and lifestyle determinants of MCI to refine prevention and management strategies across geographic settings.
UNASSIGNED: Leveraged EHRs to explore rural-urban differences in MCI in West Michigan.Revealed a significant underdiagnosis of MCI, especially in rural areas.Observed lower rates of neurological referrals and completions for rural patients.Identified risk factors specific to rural and urban populations.