目的:本研究旨在探讨低强度脉冲超声(LIPUS)对1型胶原酶诱导的大鼠跟腱病愈合的影响。
方法:本研究是在72只具有典型活动的Wistar白化病雌性大鼠的144只跟腱上进行的,体重为300-350g。通过注射1型胶原酶建立跟腱病模型。根据采样时间,4组作为对照组,8组在不同时期接受治疗。在第1、7和15天开始了8组的低强度脉冲超声治疗。治疗延长1周和2周。15日从治疗组和对照组中取出跟腱,21日,30日,第45天进行生物力学和病理检查。
结果:与对照组相比,在增殖阶段的第一天施用的LIPUS治疗使拉伸强度增加了约30%,弹性模量约为53%,纤维外观下降53%,和炎症53%-33%在较短的时间内。还证明,与2周治疗相比,即使1周治疗,在增殖期的第一天开始治疗也产生相当的成功。
结论:低强度脉冲超声治疗可以在大鼠跟腱病模型中提供积极的治疗结果。它缩短疗养时间的能力引起了人们对保守治疗方法的兴趣。因此,需要更多的临床研究。引用这篇文章:KurtulmušT,elebiME,BektašE,Arican高级别D,KucukyildirimBO,低强度脉冲超声治疗对大鼠跟腱病愈合的影响。ActaOrthopTraumatolTurc。,2024;58(2):102-109。
OBJECTIVE: This study aimed to investigate the effect of the low-intensity pulsed ultrasound (LIPUS) on the healing of Achilles tendinopathy in a rat model induced by type 1 collagenase.
METHODS: The study was conducted on 144 Achilles tendons of 72 Wistar albino female rats with typical activity and weighing 300-350 g. The model of Achilles tendinopathy was created by injecting type 1 collagenase. According to the sampling time, 4 groups served as the control group, while 8 groups received treatment at varying periods. Low-intensity pulsed ultrasound therapy was initiated in 8 groups at 1, 7, and 15 days. Treatment was extended for 1 and 2 weeks. Achilles tendons were removed from the treatment and control groups on the 15th, 21st, 30th, and 45th days for biomechanical and pathologic examination.
RESULTS: Compared to the control groups, LIPUS treatment administered in the first days of the proliferation phase increased tensile strength by approximately 30%, modulus of elasticity by approximately 53%, fibrillar appearance by 53%, and inflammation by 53%-33% in a shorter time. It was also demonstrated that starting treatment in the first days of the proliferation phase resulted in comparable success even with 1-week treatment compared to 2-week treatment.
CONCLUSIONS: Low-intensity pulsed ultrasound therapy can provide positive results in managing Achilles tendinopathy in the rat model. Its capacity to shorten recuperation time has piqued the interest of conservative treatment approaches. As a result, more clinical research is required. Cite this article as: Kurtulmuş T, Çelebi ME, Bektaş E, Arican ÇD, Kucukyildirim BO, Demirkol M. Effect of the low-intensity pulsed ultrasound therapy on healing of Achilles tendinopathy in a rat model. Acta Orthop Traumatol Turc., 2024;58(2):102-109.