■尽管炎症过程的激活对于抵抗感染至关重要,众所周知,它对大脑功能的长期影响有助于许多医学疾病的病理生理学,包括神经精神疾病.因此,确定选择性对抗神经炎症有害影响的新策略似乎是一个主要的健康问题。在这种情况下,这项研究旨在测试营养干预与藏红花的相关性,一种因对健康有益而闻名数百年的香料。
■为此,急性口服标准化藏红花提取物的影响,以前被证明具有神经调节特性并减少抑郁样行为,在接受脂多糖(LPS,830μg/kg,ip)。
■用藏红花提取物(6.5mg/kg,每个操作系统)没有减少LPS诱导的疾病行为,因此,保留了这种对宿主防御至关重要的适应性行为反应。然而,它干扰了细胞因子表达的延迟变化,在LPS治疗后24小时,在行为和情绪控制的关键大脑区域(额叶皮质,海马体,纹状体)。重要的是,到那时,这种预处理还抵消了LPS对几种神经生物学过程的影响,这些过程有助于炎症诱导的情绪改变,特别是犬尿氨酸途径的激活,通过其主要酶的表达来评估,以及伴随的5-羟色胺能和多巴胺能神经传递的损害。
■总之,这项研究为藏红花提取物在免疫刺激条件下如何干扰脑功能提供了重要线索,并支持藏红花营养干预对改善炎症相关合并症管理的相关性.
UNASSIGNED: Although activation of inflammatory processes is essential to fight infections, its prolonged impact on brain function is well known to contribute to the pathophysiology of many medical conditions, including neuropsychiatric disorders. Therefore, identifying novel strategies to selectively counter the harmful effects of neuroinflammation appears as a major health concern. In that context, this study aimed to test the relevance of a nutritional intervention with saffron, a spice known for centuries for its beneficial effect on health.
UNASSIGNED: For this purpose, the impact of an acute oral administration of a standardized saffron extract, which was previously shown to display neuromodulatory properties and reduce depressive-like behavior, was measured in mice challenged with lipopolysaccharide (LPS, 830 μg/kg, ip).
UNASSIGNED: Pretreatment with saffron extract (6.5 mg/kg, per os) did not reduce LPS-induced sickness behavior, preserving therefore this adaptive behavioral response essential for host defense. However, it interfered with delayed changes of expression of cytokines, chemokines and markers of microglial activation measured 24 h post-LPS treatment in key brain areas for behavior and mood control (frontal cortex, hippocampus, striatum). Importantly, this pretreatment also counteracted by that time the impact of LPS on several neurobiological processes contributing to inflammation-induced emotional alterations, in particular the activation of the kynurenine pathway, assessed through the expression of its main enzymes, as well as concomitant impairment of serotonergic and dopaminergic neurotransmission.
UNASSIGNED: Altogether, this study provides important clues on how saffron extract interferes with brain function in conditions of immune stimulation and supports the relevance of saffron-based nutritional interventions to improve the management of inflammation-related comorbidities.