目的:自石器时代以来,药用植物在人类健康中发挥了重要作用。根据WHO,80%的亚洲和非洲人民依靠传统医药和药用植物来保护他们的健康。藏红花在与癌症治疗相关的草药化合物中受到了广泛的关注。
方法:这篇综述旨在概述抗肿瘤活性的体外和体内评估分子机制,藏红花提取物的癌症预防和保护作用。该评论基于PubMed中可访问的可用数据,科学直接,谷歌学者,马吉兰.ir,还有SID.ir数据库。
结果:藏红花对癌细胞具有选择性毒性和预防作用,对正常细胞无不良影响,可防止肿瘤形成。藏红花似乎可以减少抗癌药物的毒性作用。藏红花在大量使用时具有毒性作用,远远大于人类饮食文化中使用的食物。
结论:考虑到藏红花对癌细胞去除的观察效果,藏红花提取物经人体临床试验证实后可用于治疗和预防癌症。根据藏红花提取物在正常细胞中的高IC50,它对非癌细胞的毒性低,使用安全。此外,研究表明藏红花对某些癌症的细胞毒性作用,包括神经系统癌症和常见癌症。需要进一步的研究来确定藏红花在各种动物类型癌症中的有效剂量和作用机制。
OBJECTIVE: Medicinal plants have played an important role in human health since the Stone Age. According to WHO, 80% of Asian and African people rely on traditional medicine and medicinal plants to conserve their health. Saffron has received much attention among the herbal compounds related to cancer treatment.
METHODS: This
review aims to provide an overview of in-vitro and in-vivo evaluation molecule mechanism for anti-tumor activity, cancer preventing and protective effects of saffron extract. The
review is based on the available data accessible in PubMed, Science Direct, Google Scholar, Magiran.ir, and SID.ir databases.
RESULTS: Saffron has selective toxic and preventive effects on cancerous cells and without adverse effects on normal cells and prevents tumor formation. Saffron appears to reduce the toxic effects of anticancer drugs. Saffron has toxicity effects when used in high amounts, which are far greater than those are used in human food culture.
CONCLUSIONS: Considering the observed effects of saffron on the removal of cancer cells, saffron extract can be used in the treatment and prevention of cancer after confirmation in human clinical trials. According to the high IC50 of saffron extracts in normal cells, its toxicity against non-cancerous cells is low and its use is safe. Besides, the studies suggested the cytotoxic effects of saffron on some of the more cancers, including nervous system cancer and common cancers. Further studies are required to determine the effective dose and influence of mechanism of saffron in various animal type of cancers.