PDF(Pubmed)
Abstract：
According to animal studies, saffron and its main volatile compound safranal may reduce biological and behavioral signs of acute stress. However, little is known about its impact in humans. This study investigated the acute effect of a saffron extract and safranal on the biological and psychological stress responses in healthy men experiencing a laboratory stress procedure. In this double-blind, placebo-controlled, randomized, cross-over study, 19 volunteers aged 18-25 received a single dose of 30 mg saffron extract (Safr\'InsideTM), 0.06 mg synthetic safranal, or a placebo on three visits separated by a 28-day washout. Thirteen minutes after administration, participants were exposed to the Maastricht acute stress test (MAST). Salivary cortisol and cortisone were collected from 15 min before the MAST (and pre-dose), 3 min before the MAST, and then 15, 30, 45, 60, and 75 min after the MAST, and stress and anxiety were measured using visual analogic scales. Compared to the placebo, stress and anxiety were significantly toned down after Safranal and Safr\'InsideTM administration and coupled with a delay in the times to peak salivary cortisol and cortisone concentrations (p < 0.05). Safr\'InsideTM and its volatile compound seem to improve psychological stress response in healthy men after exposure to a lab-based stressor and may modulate the biological stress response.
摘要：
根据动物研究,藏红花及其主要挥发性化合物藏红花可以减少急性应激的生物学和行为体征。然而,人们对它对人类的影响知之甚少。这项研究调查了藏红花提取物和savranal对经历实验室压力程序的健康男性的生物和心理应激反应的急性影响。在这个双盲中，安慰剂对照,随机化，交叉研究，19名18-25岁的志愿者接受了单剂量30毫克藏红花提取物（Safr\'InsideTM），0.06毫克合成安全，或安慰剂在三次访问中被28天的冲洗分开。给药后13分钟，参与者接受了马斯特里赫特急性应激试验(MAST).唾液皮质醇和可的松从MAST（和给药前）前15分钟收集，MAST前3分钟，然后在MAST后15、30、45、60和75分钟，使用视觉类比量表测量压力和焦虑。与安慰剂相比，Safranal和Safr\'InsideTM给药后，压力和焦虑显着减轻，唾液皮质醇和可的松浓度达到峰值的时间有所延迟（p<0.05）。Safr\'InsideTM及其挥发性化合物似乎可以改善健康男性在暴露于实验室压力源后的心理应激反应，并可能调节生物应激反应。
