■作为有效的生长促进剂和免疫调节剂,酵母发酵产品在反刍动物中显示出积极的效果。探讨酵母培养物促进生长和调节免疫的机制。这项研究调查了酵母培养的影响,β-葡聚糖作为其主要活性成分之一,关于增长表现,免疫功能,蒙古公羊羔羊的抗氧化能力和荷尔蒙分布。
■将一百零五只蒙古公羊随机分为3组,每组重复35次。饲粮处理为:以总混合日粮(TMR)为对照组,补充有50-70g/kg酵母培养物(YC)或75mg/kgβ-葡聚糖的TMR。测试期为137天。在第0、30、60、90和130天,对所有绵羊进行称重,每组收集6份血清样品。
■结果表明,YC和β-葡聚糖均可促进生长性能,平均日增重增加,饲料增重比降低。此外,这两种饲料添加剂通过选择性增加血清溶菌酶水平来促进免疫功能,IgG,IgM,INF-γ,TNF-α和一些白细胞介素(IL-1β,IL-2,IL-6和IL-8);以更高的总抗氧化能力和过氧化氢酶和谷胱甘肽过氧化物酶的酶活性改善了抗氧化能力;生长激素和甲状腺激素T3升高,皮质醇和胰岛素降低,从而改变了与代谢相关的激素水平。
■总而言之,YC和β-葡聚糖都能提高生长性能,免疫功能和抗氧化能力,调节代谢相关激素的血清水平,从而发挥促进生长和提高免疫功能的作用。因此,YC可以被认为是抗生素的合适的潜在替代策略,并可用作动物饲料添加剂。本文为此类酵母发酵制剂在肉羊养殖中的临床应用提供了理论依据。
UNASSIGNED: As effective growth-promoters and immune-modulators, yeast fermented products have shown positive effects in ruminants. To explore the mechanisms of yeast culture promoting growth and regulating immunity, this study investigated the effects of yeast culture, and β-glucan as one of its main active ingredients, on the growth performance, immune function, antioxidant capacity and hormonal profile in Mongolian ram lambs.
UNASSIGNED: One hundred and five Mongolian ram lambs were randomly assigned to 3 groups, with 35 replicates in each group. The dietary treatments were: total mixed ration (TMR) as the control group, TMR supplemented with 50-70 g/kg yeast culture (YC) or 75 mg/kg β-glucan. The test period was 137 days. All the sheep were weighed and 6 serum samples were collected in each group on days 0, 30, 60, 90 and 130, respectively.
UNASSIGNED: The results showed that both YC and β-glucan could promote the growth performance with increased average daily gain and decreased feed to weight gain ratio. Moreover, these two feed additives facilitated the immune function by selectively increasing the serum levels of lysozyme, IgG, IgM, INF-γ, TNF-α and some interleukins (IL-1β, IL-2, IL-6 and IL-8); ameliorated the antioxidant capacity with higher total antioxidant capacity and enzyme activities of catalase and glutathione peroxidase; altered the metabolism-associated hormone levels with higher growth hormone and thyroid hormone T3 but lower cortisol and insulin.
UNASSIGNED: In conclusion, both YC and β-glucan could improve the growth performance, immune function and antioxidant capacity, and regulate the serum levels of metabolism-associated hormones, thus exerting effects of promoting growth and improving immune function. Therefore, YC could be considered as a suitable potential alternative strategy to antibiotics and be used as an animal feed additive. This article provides a theoretical basis for the clinical application of such yeast fermented preparations in mutton sheep husbandry.