■为了比较不含防腐剂的地塞米松的治疗效果,NSAIDs和海藻糖/透明质酸滴眼液与含有地塞米松和NSAIDs的防腐剂苯扎氯铵在干眼与非干眼的白内障手术后。
■在这项前瞻性随机干预研究中,在白内障手术前和术后6周进行干眼试验.患者被认为患有干眼症,SDE(干眼症)如果以下干眼症测试中至少有一项异常;角膜荧光素染色(CFS),非侵入性角膜造影破裂时间(NIKBUT)或泪液渗透压。SDE患者被随机分为两组。第1组患者接受地塞米松和溴芬酸滴眼液以及防腐剂苯扎氯铵(BAC)治疗。第2组患者采用不含防腐剂的地塞米松和不含防腐剂的双氯芬酸,以及手术前后含海藻糖和透明质酸的无防腐剂润滑剂。泪膜状态正常的患者作为对照组(第3组),接受与第1组相同的治疗。
■手术后6周,共纳入215名患者,第1组和第2组的SDE患者数量显著减少(p<0.001).主观症状和客观措施,包括渗透压,NIKBUT,CFS,术后泪膜厚度(TFT)改善,泪液产量保持不变,而角膜敏感性和睑板腺功能障碍(MGD)参数恶化。正常泪膜状态的对照组,手术后SDE显著增加(p<0.001)。术后三组间泪膜参数差异无统计学意义。
■白内障手术后,轻度至中度干眼症患者的泪膜状态改善,症状减轻.然而,我们发现使用无防腐剂的地塞米松治疗对干眼参数没有额外的有益影响,NSAIDs,和润滑剂相比,含防腐剂的眼药水。
UNASSIGNED: To compare the effect of treatment with preservative-free dexamethasone, NSAIDs and trehalose/hyaluronic acid eye drops with the preservative benzalkonium chloride containing dexamethasone and NSAIDs after cataract surgery in dry versus non-dry eyes.
UNASSIGNED: In this prospective randomized intervention study, dry eye tests were performed before and 6 weeks after cataract surgery. Patients were considered as having dry eye, SDE (sign of dry eye), if at least one of the following dry eye tests were abnormal; corneal fluorescein staining (CFS), non-invasive keratograph breakup time (NIKBUT) or tear
osmolarity. Patients with SDE were randomly assigned to one of two groups. Group 1 patients were treated with dexamethasone and bromfenac eye drops with the preservative benzalkonium chloride (BAC). Group 2 patients were treated with preservative-free dexamethasone and preservative-free diclofenac, as well as a preservative-free lubricant with trehalose and hyaluronic acid both before and after surgery. Patients with normal tear film status acted as the control group (group 3) and received same treatment as group 1.
UNASSIGNED: A total of 215 patients were enrolled six weeks after surgery, the number of patients with SDE decreased significantly in groups 1 and 2 (p <0.001). Subjective symptoms and objective measures including
osmolarity, NIKBUT, CFS, and tear film thickness (TFT) improved after surgery, tear production remained unchanged, while corneal sensitivity and meibomian gland dysfunction (MGD) parameters worsened. In the control group with normal tear-film status, SDE increased significantly after the surgery (p <0.001). There were no statistically significant differences in tear film parameters between the three groups after surgery.
UNASSIGNED: After cataract surgery, patients with mild to moderate dry eyes may experience improved tear film status and reduced symptoms. However, we found no additional beneficial effect on dry eye parameters with treatment with preservative-free dexamethasone, NSAIDs, and lubricants compared to preservative-containing eye drops.