PDF(Pubmed)
Abstract：
UNASSIGNED: The primary objective was to investigate if treatment with artificial tears affected the variability of keratometry measurements for subjects with dry eyes prior to cataract surgery. The secondary objectives were to investigate whether treatment with artificial tears improved refractive precision and whether subjects with non-dry eyes had better refractive precision than subjects with dry eyes.
UNASSIGNED: Prospective randomized controlled trial with three arms.
UNASSIGNED: Dry eye diagnostics according to DEWS II were performed, and subjects with dry eyes were randomized to no treatment (group A1) or treatment with artificial tears two weeks prior to cataract surgery (group A2), with the third group (Group B, non-dry eyes) as a control. Keratometry was performed twice at baseline and twice after two weeks at the time of cataract surgery with three different optical biometers. The change in mean variability of keratometry (average K and magnitude of vector differences) and percentages of outliers after two weeks versus baseline were compared for group A2. The refractive and astigmatism prediction errors were calculated eight weeks after cataract surgery and compared for all three groups.
UNASSIGNED: One hundred thirty-one subjects were available for analysis. There was no statistically significant difference in the mean variability of keratometry or percentages of outliers for group A2 from baseline to the time of cataract surgery. There was no statistically significant difference in refractive precision (absolute error and astigmatism prediction error) between any groups.
UNASSIGNED: Subjects with dry eyes (treated and non-treated) achieved the same refractive precision and percentages of outliers as subjects with non-dry eyes. Treatment with artificial tears for two weeks appeared inadequate to significantly affect variability in biometric measurements for patients with dry eyes prior to cataract surgery. DEWS II criteria for DED may not be optimal in a cataract setting.
UNASSIGNED: Prospective randomized controlled trial with three arms.
UNASSIGNED: Dry eye diagnostics according to DEWS II were performed, and subjects with dry eyes were randomized to no treatment (group A1) or treatment with artificial tears two weeks prior to cataract surgery (group A2), with the third group (Group B, non-dry eyes) as a control. Keratometry was performed twice at baseline and twice after two weeks at the time of cataract surgery with three different optical biometers. The change in mean variability of keratometry (average K and magnitude of vector differences) and percentages of outliers after two weeks versus baseline were compared for group A2. The refractive and astigmatism prediction errors were calculated eight weeks after cataract surgery and compared for all three groups.
UNASSIGNED: One hundred thirty-one subjects were available for analysis. There was no statistically significant difference in the mean variability of keratometry or percentages of outliers for group A2 from baseline to the time of cataract surgery. There was no statistically significant difference in refractive precision (absolute error and astigmatism prediction error) between any groups.
UNASSIGNED: Subjects with dry eyes (treated and non-treated) achieved the same refractive precision and percentages of outliers as subjects with non-dry eyes. Treatment with artificial tears for two weeks appeared inadequate to significantly affect variability in biometric measurements for patients with dry eyes prior to cataract surgery. DEWS II criteria for DED may not be optimal in a cataract setting.
摘要：
主要目的是研究用人工泪液治疗是否影响白内障手术前干眼受试者的角膜曲率测量的变异性。次要目标是研究用人工泪液治疗是否改善屈光精度，以及非干眼受试者的屈光精度是否优于干眼受试者。
■三组前瞻性随机对照试验。
■根据DEWSII进行干眼诊断，干眼症患者在白内障手术前两周随机分为不治疗（A1组）或人工泪液治疗（A2组），第三组(B组，非干眼）作为对照。使用三种不同的光学生物测定仪在基线时进行两次，在白内障手术时两周后进行两次。比较A2组的角膜曲率测量的平均变异性（平均K和矢量差异的大小）和两周后异常值的百分比与基线的变化。在白内障手术后8周计算屈光和散光预测误差，并对所有三组进行比较。
■一百三十一名受试者可用于分析。从基线到白内障手术时间，A2组的角膜曲率测量的平均变异性或异常值百分比没有统计学上的显着差异。任何组之间的屈光精度（绝对误差和散光预测误差）没有统计学上的显着差异。
■干眼（治疗和未治疗）的受试者获得了与非干眼受试者相同的屈光精度和异常值百分比。用人工泪液治疗两周似乎不足以显着影响白内障手术前干眼患者的生物特征测量的变异性。DEWSII标准在白内障环境中可能不是最佳的。
■三组前瞻性随机对照试验。
■根据DEWSII进行干眼诊断，干眼症患者在白内障手术前两周随机分为不治疗（A1组）或人工泪液治疗（A2组），第三组(B组，非干眼）作为对照。使用三种不同的光学生物测定仪在基线时进行两次，在白内障手术时两周后进行两次。比较A2组的角膜曲率测量的平均变异性（平均K和矢量差异的大小）和两周后异常值的百分比与基线的变化。在白内障手术后8周计算屈光和散光预测误差，并对所有三组进行比较。
■一百三十一名受试者可用于分析。从基线到白内障手术时间，A2组的角膜曲率测量的平均变异性或异常值百分比没有统计学上的显着差异。任何组之间的屈光精度（绝对误差和散光预测误差）没有统计学上的显着差异。
■干眼（治疗和未治疗）的受试者获得了与非干眼受试者相同的屈光精度和异常值百分比。用人工泪液治疗两周似乎不足以显着影响白内障手术前干眼患者的生物特征测量的变异性。DEWSII标准在白内障环境中可能不是最佳的。
